-
摘要: 目的: 探讨急性重症秋水仙碱中毒的救治策略。方法: 回顾性分析2014-01-2017-11期间收治的5例急性重症秋水仙碱中毒的临床资料, 均为大剂量服毒自杀, 其中男2例, 女3例;年龄21~56岁, 平均 (38.8±14.1) 岁。结果: 2例死亡, 1例放弃治疗后死亡, 2例临床治愈出院。结论: 虽然秋水仙碱中毒虽无特殊解毒药, 治疗上仍以对症处理及重要脏器功能保护为主。但是, 通过分析中毒后患者的症状、治疗及并发症, 我们认为, 如果能尽早积极清除毒物, 尤其是配合及时血液滤过及血浆置换的综合治疗, 还是能有较好的救治效果。Abstract: Objective: To investigate the therapeutic strategy on patients with acute severe colchicine poisoning.Method: Five acute colchicine poisoning cases admitted to our department from January 2014 to November 2017 were retrospectively analyzed.All cases, which include 2 males and 3 females at 21-56 years old with an average of (38.8 ± 14.1) year, are suicides with high dose.Result: Among these cases, 2 cases died, 1 case died after giving up treatment, 2 cases were cured and discharged from hospital.Conclusion: Although there is no special antidote for poisoning caused by colchicine, and the treatment mainly focuses on the symptomatic treatment and protection of the functions of important organs.However, we believe that if we can actively remove toxic substances as early as possible, especially combined with timely hemofiltration and plasma exchange after analyzing the symptoms, treatment and complications of patients, we can also achieve better therapeutic effect on patients with colchicine poisoning.
-
Key words:
- colchicine /
- severe poisoning /
- comprehensive treatment
-
-
[1] 赵敏, 王玉芝.急性秋水仙碱中毒与多器官功能衰竭 (附1例报道)[J].中国急救医学, 2003, 23 (8):590-591.
[2] 中华医学会风湿病学分会.2016中国痛风指南[J].中华内科杂志, 2016, 55 (11):892-899.
[3] 英国风湿病学会.2017年痛风管理指南推荐要点[J].临床误诊误治, 2017, 33 (8):2+117.
[4] Zouboulis C C, Turnbull J R, Muhlradt P F.Association of mycoplasma fermentans with AdamantiadesBehcetf's disease[J].Adv Exp Med Biol, 2003, 528:191-194.
[5] Terkeltaub R A.Colchicine update:2008[J].Semin Arthritis Rheum, 2009, 38:411-419.
[6] 何新华, 李春盛, 张海燕, 等.极量秋水仙碱中毒并发多脏器功能衰竭1例[J].中国急救医学, 2009, 29 (2):189-190.
[7] Mullins M E, Robertson D G, Norton R L.Troponin I as a msrker of cardiac toxicity in acute colshicine overdoes.[J].Am J Emerg Med, 2000, 18:743-744.
[8] 牛文凯, 邱泽武.秋水仙碱中毒的诊断与处理[J].药物不良反应杂志, 2006, 8 (5):368-369.
[9] Atas B, Caksen H, Tuncer O, et al.Four chindren with colchicines poisoning[J].Hum Exp Toxicol, 2004, 23:353-356.
-
计量
- 文章访问数: 301
- PDF下载数: 974
- 施引文献: 0