神经生长因子联合神经节苷脂对弥漫性轴索损伤患者神经保护作用及其对血清及脑脊液中髓鞘碱性蛋白含量的影响

费立博; 狄佳; 陈慧敏; 聂时南

doi:10.13201/j.issn.1009-5918.2018.04.013

神经生长因子联合神经节苷脂对弥漫性轴索损伤患者神经保护作用及其对血清及脑脊液中髓鞘碱性蛋白含量的影响

- 南京大学医学院附属金陵医院(南京军区南京总医院)急救医学科(南京, 210002)

详细信息

通讯作者: 聂时南, E-mail:shn_nie@sina.com

中图分类号: R651.15

收稿日期: 2018-02-05

The influence of neuroprotective effect and the content of myelin basic protein in serum and cerebrospinal of nerve growth factor combined with monosialotetrahexosy-1 ganglioside in the treatment of diffuse axonal injury

- Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing, 210002, China

More Information

Corresponding author: NIE Shinan, E-mail: shn_nie@sina.com

Received Date: 05 February 2018

摘要

摘要: 目的: 研究神经生长因子 (NGF) 联合神经节苷脂 (GM1) 对弥漫性轴索损伤 (DAI) 神经保护作用及其对血清及脑脊液中髓鞘碱性蛋白 (MBP) 含量的影响。方法: 选择符合诊断标准100例患者随机分为治疗组和对照组, 每组50例, 用Elisa法测定两组患者治疗前及治疗后第1、3、7、20天血清及脑脊液中MBP水平。结果: 两组治疗后血清和脑脊液MBP水平均有不同程度下降, 治疗组术后第3、7、20天血清和脑脊液MBP水平显著低于对照组。且治疗结束后6个月随访, 治疗组显效率显著高于对照组。结论: DAI患者早期联合应用NGF和GM1能减少血清和脑脊液中MBP含量, 从而减少神经细胞凋亡, 促进损伤的神经元修复, 发挥其脑保护作用。
- 神经生长因子 /
- 神经节苷脂 /
- 弥漫性轴索损伤 /
- 髓鞘碱性蛋白
Abstract: Objective: To study the influence of neuroprotective effect and the content of myelin basic protein (MBP) in serum and cerebrospinal of nerve growth factor (NGF) combinedwith monosialotetrahexosy-1 ganglioside (GM1) in the treatment of diffuse axonal injury (DAI).Method: One hundred patients accord with diagnostic criteria were selected and randomly divided into treatment group and the control group, 50 cases in each group, the content of MBP in serum and cerebrospinal of patients were measured by Elisa at 1, 3, 7, 20 days.Result: Serum and cerebrospinal MBP levels of the two groups after treatment decreased to varying degrees;after 3, 7, 20 days, the serum and cerebrospinal MBP levels of treatment group were significantly lower than the control group.Followed-up6 months after the end of treatment, effective rate of treatment group was significantly higher than that in the control group.Conclusion: Early combined use of NGF and GM1 in patients with DAI can reduce the content of MBP in serum and cerebrospinal, reducing the apoptosis of neurons and promoting the repairment of injured neurons.
- nerve growth factor /
- monosialotetrahexosy-1ganglioside /
- diffuse axonal injury /
- myelin basic protein

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