热毒宁注射液辅助治疗对急性胆囊炎术后患者炎症指标及免疫功能的影响

陈佳骏; 张海阳; 曲岩; 曹学冬; 宋鑫

doi:10.13201/j.issn.1009-5918.2021.08.006

热毒宁注射液辅助治疗对急性胆囊炎术后患者炎症指标及免疫功能的影响

- 上海中医药大学附属曙光医院肝胆外科(上海, 201203)

详细信息

通讯作者: 张海阳,E-mail:13918287755@163.com

中图分类号: R285.6

收稿日期: 2021-06-23

Effect of adjuvant Reduning injection on inflammatory reaction and immune function in patients with acute cholecystitis after operation

- Department of Hepatobiliary Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

More Information

Corresponding author: ZHANG Haiyang, E-mail: 13918287755@163.com

Received Date: 23 June 2021

摘要

摘要: 目的:探讨热毒宁注射液(下称热毒宁)辅助治疗对急性胆囊炎术后患者炎症指标及免疫功能的影响。方法:将2020年1月-2020年6月期间在本院接受腹腔镜胆囊切除术治疗的急性胆囊炎患者纳入研究,采用随机数字表法将患者随机分为热毒宁干预组和对照组。两组患者均接受手术及预防性抗感染等常规治疗,热毒宁干预组患者加用热毒宁注射液干预,比较两组患者体温改善时长、炎症指标、淋巴细胞亚群及不良反应发生率的差异。结果:热毒宁干预组患者更快恢复至正常体温(P<0.05)。热毒宁干预组患者治疗2 d后,血液中CD3+、CD4+淋巴细胞水平增高更显著,CD8+淋巴细胞水平下降更明显,且血清CRP、PCT水平更低,与对照组比较,差异均具有统计学意义(P<0.05)。热毒宁注射液的应用不增加不良反应的发生率(P>0.05)。结论:在腹腔镜胆囊切除及预防性抗感染治疗等常规治疗基础上,加用热毒宁注射液可有效缩短急性胆囊炎患者体温恢复至正常水平的时间,其机制可能与抑制炎症反应并改善患者免疫状态相关。
- 热毒宁 /
- 急性胆囊炎 /
- 炎症因子 /
- 免疫功能
Abstract: Objective: To investigate the effect of adjuvant Reduning injection on inflammatory indexes and immune function in patients with acute cholecystitis after surgery.Methods:The patients with acute cholecystitis who underwent laparoscopic cholecystectomy in our hospital from January 2020 to June 2020 were included in the present study, and the patients were randomly divided into the Reduning intervention group and the control group using a random number table method.Both groups of patients received conventional treatments such as surgery and preventive anti-infection.Patients in the Reduning intervention group were treated with Reduning injection.The duration of temperature improvement, inflammation indicators, lymphocyte subsets and incidence of adverse reactions were compared between the two groups.Results:The patients in the Reduning intervention group recovered to normal body temperature faster(P<0.05).After 2 days of treatment in the Reduning treatment group, level of CD3+ and CD4+ lymphocytes in the blood increased more significantly, level of CD8+ lymphocytes decreased more significantly, and the serum CRP and PCT levels were lower.The differences compared with the control group were statistically significant(P<0.05).Reduning application did not increase the incidence of adverse reactions(P>0.05).Conclusion:On the basis of conventional treatment such as laparoscopic cholecystectomy and prophylactic use of antibiotics, Reduning intervention can effectively shorten the time length for recovering to normal temperature in patients with acute cholecystitis after operation, and its mechanism may be related to inhibite inflammatory reaction and improve immune status of patients.
- Reduning /
- acute cholecystitis /
- inflammatory indexes /
- immune function

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参考文献(20)

[1]	张惠颖.疏肝利胆汤对急性胆囊炎中医证候积分、免疫球蛋白及血清炎症因子表达的影响[J].中国中医急症,2018,27(7):1239-1241.
[2]	吴彩霞,张娟娟,顾雪竹,等.热毒宁注射液的临床应用概况[J].中国药房,2014,25(7):666-669.
[3]	葛雯,李海波,于洋,等.热毒宁注射液化学成分、药理作用及临床应用研究进展[J].中草药,2017,48(5):1027-1036.
[4]	孙兰,周军,王振中.热毒宁注射液药理作用与临床研究进展[J].中国中医急症,2014,23(12):2247-2249.
[5]	赵吟,邓彧斐.热毒宁注射液对儿童急性喉气管炎免疫功能及炎性反应的影响[J].世界中医药,2019,14(4):962-965.
[6]	李红松.腹腔镜胆囊切除术联合中药治疗急性结石性胆囊炎的疗效观察[J].海南医学,2014,25(5):658-660.
[7]	Duan X,Wang K,Wu J,et al.Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children:A Bayesian network meta-analysis of randomized controlled trials[J].J Clin Pharm Ther,2019,44(5):675-684.
[8]	Cao C,Zhen Z,Kuang S,et al.Reduning injection combined with western medicine for pneumonia:A protocol for systematic review and meta-analysis[J].Medicine(Baltimore),2020,99(43):e22757.
[9]	张丽勇,林秀梅,战月,等.不同方法提取青蒿挥发油成分分析及抗菌活性比较[J].中国实验方剂学杂志,2011,17(22):60-63.
[10]	姚财文.热毒宁注射液的药理作用、临床应用及不良反应分析[J].中国医学文摘(耳鼻咽喉科学),2017,32(5):256-257,264.
[11]	冯欣煜,姚志凌,李明辉.金银花的现代药理和临床运用研究进展[J].中医研究,2015,28(9):4.
[12]	杨宜花,洪婷.中药栀子在复方配伍中的功效发微[J].中医文献杂志,2016,34(5):24-26.
[13]	韩建萍,陈士林,张文生,等.不同产地桅子药材HPLC指纹图谱研究[J].世界科学技术-中医药现代化,2007,9(4):56-60.
[14]	Zhang D,Zhang B,Lv JT,et al.The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence[J].Pharmacol Res,2020,157:104882.
[15]	余长升,马艳红,辛晓婷.降钙素原、C反应蛋白清除率对脓毒性休克患者的预后价值[J].临床急诊杂志,2020,21(6),482-487.
[16]	Becker KL,Snider R,Nylen ES.Procalcitonin assay in systemic inflammation,infection,and sepsis:clinical utility and limitations[J].Crit Care Med,2008,36(3):941-52.
[17]	张红,倪诤,张丽英,等.急诊快速PCT检测对评估脓毒症预后的意义[J].临床急诊杂志,2015,16(1):21-23.
[18]	郭伟,李平,陈翠.脓毒症诱导T细胞功能紊乱及免疫治疗进展[J].临床急诊杂志,2020,21(9):758-762.
[19]	Li SL,Xu YH,Wang X,et al.Effects of enteral immunonutrition on immune function in patients with multiple trauma[J].World J Emerg Med,2011,2(3):206-209.
[20]	伍伟光,蔡芳芳,林幼萍,等.mHLA-DR%联合CD4+/CD8+比值对严重创伤患者临床结局的预测作用[J].临床急诊杂志,2017,18(10):763-767.