Research progress on the role and mechanism of Rho/ROCK signaling pathway in sepsis-related organ damage
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Abstract: Rho kinase(ROCK) is a downstream effector protein of Rho. It is involved in many biological behaviors, such as cytoskeleton reorganization, endothelial cell function regulation, inflammatory cell infiltration and apoptosis. Studies have shown that the activation or increased expression of Rho/ROCK signaling pathway is closely related to the occurrence and development of sepsis. In recent years, ROCK inhibitors have become a research hotspot in the treatment of sepsis. This article reviews the research progress of Rho/ROCK pathway in sepsis-related diseases, and provides new ideas for the prevention and treatment of sepsis.
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Key words:
- Rho/ROCK signaling pathway /
- sepsis /
- visceral injury /
- inflammation /
- apoptosis /
- endothelial dysfunction
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