敌草快的中毒机制和治疗研究进展

陈阳; 刘昊; 董雪松

doi:10.13201/j.issn.1009-5918.2021.07.013

敌草快的中毒机制和治疗研究进展

- 中国医科大学附属第一医院急诊科(沈阳, 110001)
基金项目:
国家自然科学基金面上项目(No:81971821)

详细信息

通讯作者: 董雪松,E-mail:dongxues@163.com

中图分类号: R595.4

收稿日期: 2021-04-27

Mechanism and treatment of diquat poisoning

More Information

Corresponding author: DONG Xuesong, E-mail: dongxues@163.com

Received Date: 27 April 2021

摘要

- 敌草快 /
- 中毒机制 /
- 氧化应激 /
- 炎症 /
- 治疗
Abstract: Diquat(DQ) is a non-selective quick-acting biocidal herbicide. Due to the gradual withdrawal of paraquat(PQ) from China's market, DQ is increasingly widely used in agriculture and clinical. DQ poisoning cases have increased significantly. DQ can cause oxidative stress in the body to produce overloaded reactive oxygen species and reactive nitrogen species, which directly or indirectly cause inflammation, disturb the body's original redox level and the normal state of body substances, damage organism and even cause multiple organs dysfunction. There is no specific antidote for DQ currently. The treatment after DQ poisoning is based on general poisoning treatment measures and reference to PQ poisoning, anti-oxidation, removal of inflammatory mediators, and prevention of organ function damage and so on. But the lethal rate is still so high that it has become one of difficulties in poisoning research. Many scholars conducted research on the mechanism of DQ poisoning and antioxidant drugs in the past, and issued papers saying that many drugs can inhibit oxidative stress after DQ poisoning, improve the growth performance of DQ poisoning, and reduce the damage of organ function. However, there is a lack of research on the clinical applicability of the drug and expert consensus on it. This article mainly discusses the poisoning mechanism of DQ, its influence on basic substances, toxic effects and treatments, and provides directions and ideas for future research.
- diquat /
- poisoning mechanism /
- oxidative stress /
- inflammation /
- treatment

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