-
Abstract: Sepsis is a severe clinical syndrome related to host response to infection and is one of the leading causes of in-hospital mortality worldwide. However, the treatment of sepsis is not satisfactory, there is no specific treatment plan for sepsis.Early detection and treatment is very important. In recent years for the prognosis of sepsis, with the continuous study of sepsis, a series of predictors was appeared, e.g.CRP,PCT, lactic acid value etc. with the continuous study of sepsis, but new or complementary biomarkers are needed to perfect the early warning of sepsis. Progranulin(PGRN) has been found to play a certain role in the development of sepsis and related to the prognosis of sepsis, PGRN participate in the pathogenesis of sepsis via a variety of ways including the innate immune activation, the regulation of inflammation, cell apoptosis etc. Therapeutic administration of recombinant PGRN(rPGRN) could increase bacteria clearance rate, reduce organ damage and mortality. In this review, we summarize recent advances in PGRN and its role in sepsis
-
Key words:
- sepsis /
- progranulin /
- prognosis /
- treatment
-
-
[1] Bateman A,Cheung ST,Bennett HPJ.A Brief Overview of Progranulin in Health and Disease[J].Methods Mol Biol,20181806:3-15.
[2] Yu Y,Xu X,Liu L,et al.Progranulin deficiency leads to severe inflammation,lung injury and cell death in a mouse model of endotoxic shock[J].J Cellular Molecular Med,2016,20(3):506-517.
[3] Zhang H,Li Y,van der Poll T.Immune Modulation in Sepsis:Is There a Place for Progranulin?[J].Am J Res Crit Care Med,2016,194(10):1179-1180.
[4] Song Z,Zhang X,Zhang L,et al.Progranulin Plays a Central Role in Host Defense during Sepsis by Promoting Macrophage Recruitment[J].Am J Res Crit Care Med,2016,194(10):1219-1232.
[5] Abella V,Pino J,Scotece M,et al.Progranulin as a biomarker and potential therapeutic agent[J].Drug Discovery Today,2017,22(10):1557-1564.
[6] Choi JP,Park SY,Moon KA,et al.Macrophage-derived progranulin promotes allergen-induced airway inflammation[J].Allergy,2019.
[7] Ungurs MJ,Sinden NJ,Stockley RA.Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD[J].Am J Physiol,2014,306(1):L80-L87.
[8] Kumar V.The complement system,toll-like receptors and inflammasomes in host defense:three musketeers' one target[J].Int Reviews Immunol,2019,38(4):131-156.
[9] Chousterman BG,Swirski FK,Weber GF.Cytokine storm and sepsis disease pathogenesis[J].Seminars Immunopathol,2017,39(5):517-528.
[10] Yin F,Banerjee R,Thomas B,et al.Exaggerated inflammation,impaired host defense,and neuropathology in progranulin-deficient mice[J].J Exp Med,2010,207(1):117-128.
[11] Fu W,Hu W,Shi L,et al.Foxo4-and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis[J].FASEB,2017,31(4):1354-1367.
[12] Wei F,Zhang Y,Zhao W,et al.Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions[J].PloS One,2014,9(11):e112110.
[13] Yan W,Ding A,Kim HJ,et al.Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation[J].J Immunol,2016,197(8):3393-3405.
[14] Hettinghouse A,Gao G,Liu CJ.A novel mechanism of EAE resistance highlights the conflicting roles of progranulin-mediated immunosuppression and antigen processing[J].Cellular Molecular Immunol,2019.
[15] Wang H,Ward MF,Sama AE.Targeting HMGB1 in the treatment of sepsis[J].Exp Opinion Therapeutic Targets,2014,18(3):257-268.
[16] Grégoire M,Tadié JM,Uhel F,et al.Frontline Science:HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock[J].J Leukocyte Biol,2017,101(6):1281-1287.
[17] Xu X,Gou L,Zhou M,et al.Progranulin protects against endotoxin-induced acute kidney injury by downregulating renal cell death and inflammatory responses in mice[J].Int Immunopharmacol,2016,38:409-419.
[18] Takebe M,Oishi H,Taguchi K,et al.Inhibition of histone deacetylases protects septic mice from lung and splenic apoptosis[J].J Surg Res,2014,187(2):559-570.
[19] Xie W,Lu Q,Wang K,et al.miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin[J].J Cellular Physiol,2018,233(9):6615-6631.
[20] Lee KY,Park SY,Park S,et al.Progranulin protects lung epithelial cells from cigarette smoking-induced apoptosis[J].Respirology,2017,22(6):1140-1148.
[21] Perner A,Gordon AC,De Backer D,et al.Sepsis:frontiers in diagnosis,resuscitation and antibiotic therapy[J].Intensive Care Med,2016,42(12):1958-1969.
[22] Hofer N,Zacharias E,Müller W,et al.An update on the use of C-reactive protein in early-onset neonatal sepsis:current insights and new tasks[J].Neonatology,2012,102(1):25-36.
[23] Parli SE,Trivedi G,Woodworth A,et al.Procalcitonin:Usefulness in Acute Care Surgery and Trauma[J].Surgical infections,2018,19(2):131-136.
[24] Rao L,Song Z,Yu X,et al.Progranulin as a novel biomarker in diagnosis of early-onset neonatal sepsis[J].Cytokine,2020,128:155000.
[25] He Y,Chen J,Liu Z,et al.Efficacy and safety of applying a neonatal early-onset sepsis risk calculator in China[J].J Paediat Child Health,2020,56(2):237-243.
[26] 储珍玉,侯淼,黄芳,等.颗粒体上皮蛋白前体在脓毒血症中的变化及其与疾病严重程度的关系[J].广东医学,2019,40(10):2890-2893.
[27] Tang W,Lu Y,Tian QY,et al.The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice[J].Science,2011,332(6028):478-484.
-
计量
- 文章访问数: 103
- PDF下载数: 76
- 施引文献: 0
下载: