TLRs/NF-κB和MAPK信号通路在脓毒症心肌病的研究进展

乔楚珂; 单鸿伟

doi:10.13201/j.issn.1009-5918.2020.07.017

TLRs/NF-κB和MAPK信号通路在脓毒症心肌病的研究进展

乔楚珂¹,
单鸿伟^2, ,

- 1 内蒙古医科大学第一临床医学院(呼和浩特, 010100);
- 2 内蒙古医科大学附属医院急诊科
基金项目:
内蒙古医科大学“科技百万工程”项目(No:YKD2015KJBW016)

详细信息

通讯作者: 单鸿伟,E-mail:shw1602@163.com

中图分类号: R542.2

收稿日期: 2020-04-17

Progression in the study of the Toll/NF-κB and MAPK signaling pathways in sepsis cardiomyopathy

QIAO Chuke¹,
SHAN Hongwei^2, ,

More Information

Corresponding author: SHAN Hongwei, E-mail: shw1602@163.com

Received Date: 17 April 2020

摘要

- 脓毒症心肌病 /
- Toll样受体家族 /
- 核因子κB /
- 丝裂原活化蛋白激酶 /
- 心肌抑制
Abstract: Sepsis is a systemic inflammatory response syndrome caused by the interaction between the host's immune system and invading pathogens.Severe cases can develop severe sepsis and septic shock.Sepsis cardiomyopathy is a reversible cardiac dysfunction characterized by enlarged left ventricle and decreased ejection fraction which can complete return to normal in 7-10 days.It is common in patients with severe sepsis and is the main cause of death.Although the exact mechanism by which sepsis causes cardiac dysfunction is unclear,TLRs act as immunomodulators to regulate specific signaling pathways during the immune response and play an important role in myocardial suppression caused by sepsis cardiomyopathy.Now relevant researches were reviewed.
- sepsis-induced cardiomyopathy /
- Toll-like receptors /
- NF-κB /
- mitogen-activated protein kinase /
- myocardial depression

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