血浆成纤维细胞生长因子23对急性心肌梗死合并心源性休克患者预后的预测价值

陈功雷; 郑志鹏; 窦燕; 郁毅刚; 梁伟

doi:10.13201/j.issn.1009-5918.2016.08.019

血浆成纤维细胞生长因子23对急性心肌梗死合并心源性休克患者预后的预测价值

- 厦门大学附属东南医院(福建漳州, 363000)

详细信息

通讯作者: 郑志鹏,E-mail:18960106779@163.com

中图分类号: R541

收稿日期: 2016-06-17

Predictive value of FGF-23for the prognosis of cardiac shock patients with AMI

- Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China

More Information

Corresponding author: ZHENG Zhipeng, E-mail: 18960106779@163.com

Received Date: 17 June 2016

摘要

摘要: 目的:探讨血浆成纤维细胞生长因子23(FGF-23)对急性心肌梗死合并心源性休克患者预后的预测价值。方法:选择2014-01-2015-06收入我院重症医学科的52例急性心肌梗死合并心源性休克的患者。收集患者入院时年龄、性别、BMI、心率等一般资料,记录患者入院时和治疗2 d后的血浆FGF-23水平、肌酐、乳酸、肌钙蛋白T水平。根据患者入院28 d的患者存活情况,分为存活组(n=28)和死亡组(n=24)。分析各参数并评估其对短期预后的预测价值。结果:2组患者在性别、年龄、BMI、心率等方面差异无统计学意义。对比入院时和住院2 d后患者的血浆FGF-23水平、肌酐、乳酸、肌钙蛋白T、血磷水平,死亡组均显著性升高(P<0.001)。对比2组患者入院时和治疗2天后血钙水平,其中入院时2组患者的血钙水平差异无统计学意义;治疗2 d后2组患者的血钙水平显著性升高(P<0.001)。经Pearson相关性分析发现,血FGF-23水平和患者的病死率呈正相关。结论:在急性心肌梗死合并心源性休克的患者中,FGF-23是一个预后危险预测价值,血浆FGF-23水平高的患者存在更高的短期死亡风险。
- 成纤维细胞生长因子23 /
- 急性心肌梗死 /
- 心源性休克
Abstract: Objective:Assess the predictive value of fibroblast growth factor 23 for clinical outcome of cardiogenic shock patients with acute myocardial infarction.Method:Fifty-two cardiogenic shock patients with acute myocardial infarction admitted in the ICU of our hospital between Jan 2014 and Jun 2015 were selected.Ordinary materials such as age,gender,BMI,heart rate of patients on admission were collected.Plasma level of FGF-23,creatinine,lactic acid,troponin T levels on admission and 2 days after treatment were also collected.According to the survival situation of the patients 28 days after the admission,they were divided into survival group (n=28) and death group (n=24).Each parameter was analyzed and its predictive value for the short-term prognosis was assessed.Result:There is no significant difference in age,gender,BMI,heart rate in two groups (P<0.05).Plasma level of FGF-23,creatinine,blood lactic acid,troponin T were significantly higher in the death group than those in the surivial group on admission and two days later (P<0.001).Calcium level had no significant difference between two groups on admission (P=0.077),and it was significantly increased after two days hospitalization in both groups (P<0.001).Blood FGF-23 level and the death of patients were found positively correlated by the Pearson correlation analysis.Conclusion:In cardiac shock patients with acute myocardial infarction,FGF-23 is an independent predictive factor for prognosis.High FGF-23 is independently related to a poor clinical outcome.
- fibroblast growth factor 23 /
- acute myocardial infarction /
- cardiogenic shock

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