Relationship between inflammatory markers and disease severity in sepsis
-
摘要: 目的:探讨脓毒症细菌感染患者血中白细胞计数(WBC)、C-反应蛋白(CRP)、降钙素原(PCT)等炎性指标的差异及其与疾病严重程度的相关性。方法:回顾性分析2015-01-2016-01入住我院确诊为脓毒症患者的临床资料120例,入选患者均血培养阳性并为细菌性感染患者。分析各炎症指标与病情严重程度相关性时,将其按病情严重程度分为早期脓毒症组、严重脓毒症组和脓毒症休克组;观察指标为WBC、CRP、PCT等炎性指标水平,从而评估这些炎症指标对病情严重程度。结果:早期脓毒症组、严重脓毒症组和脓毒症休克组脓毒症的CRP、PCT水平,比较差异均有统计学意义(P<0.05)。结论:PCT水平对脓毒症患者病情严重程度具有指导意义。患者PCT水平越高,病情越重。Abstract: Objective:To discuss the relationship between inflammatory markers such as white blood cell count (WBC),C-reactive protein (CRP),procalcitonin (PCT) and so on,and disease severity in patients with sepsis.Method:Retrospectively analyze clinical data of 120 patients with sepsis admitted in our hospital from January 2015 to January 2016.All had positive blood culture and were bacterial infection.According to the severity,the patients were divided into early sepsis group,severe sepsis group and septic shock group.White blood cell count (WBC),C-reactive protein (CRP),procalcitonin (PCT) and other inflammatory markers were observed and their relationship with the severity of the disease was assessed.Result:The difference of the levels of C-reactive protein,procalcitonin in early sepsis group,severe sepsis group and septic shock group was statistically significant (P<0.05).Conclusion:PCT level has guiding significance to disease severity in patients with sepsis.Patients with higher procalcitonin levels are more severe.
-
Key words:
- bloodstream infection /
- sepsis /
- procalcitonin /
- C-reactive protein /
-
-
[1] 汪江萍,刘自光,郭彩云,等.降钙素原、乳酸、D-二聚体水平与脓毒血症患儿病情的关系[J].热带医学杂志,2013,13(8):979-981.
[2] 高雯,高惠丽,解光越,等.血清降钙素原在脓毒症患儿早期诊断中的意义[J].中国实验诊断学,2014,17(10):1716-1717.
[3] 沈君,梁妤婷,左云龙,等.降钙素原与小儿脓毒血症相关性的研究[J].中国临床医生,2013,41(2):52-54.
[4] 李运璧,彭茜,朱小石,等.降钙素原对儿童脓毒症早期诊断的临床意义[J].实用医院临床杂志,2013,10(6):163-164.
[5] 李林祖,张明真,黄诚花,等.儿童全身炎症反应综合征与血清降钙素原的相关性研究[J].中国处方药,2015,(4):1-2.
[6] 伍方红,许得泽,韦继政,等.降钙素原及C反应蛋白检测在术后重度脓毒血症患者预后判断中的意义[J].广东医学,2013,34(9):1369-1371.
[7] 蒋贤高,汪晓波,王仁数,等.脓毒血症患者监测血清降钙素原、C反应蛋白的临床意义[J].中国呼吸与危重监护杂志,2009,8(5):429-431.
[8] 陈艳,王天.降钙素原对脓毒血症患者的早期诊断及预后判断的意义[J].中国医药指南,2014,12(19):45-46.
[9] 刘亚娟,郝水晶.降钙素原在脓毒血症临床治疗中的应用[J].中国社区医师(医学专业),2012,14(6):248-248.
[10] 李远华,宋秀婵,戚应静,等.血浆降钙素原浓度水平测定在脓毒血症中的应用价值[J].实用临床医药杂志,2014,18(15):155-157.
[11] 降钙素原急诊临床应用专家共识组.降钙素原(PCT)急诊临床应用的专家共识[J].中华急诊医学杂志,2012,21(9):944-951.
[12] Stocker M,Fontana M,El Helou S,et al.Use of procalcitonin guide decision making to shorten antibiotic therapy insuspected neonatal early-onset sepsis:prospective randomized intervention trial[J].Neonatology,2010,97(2):165-174.
[13] Thiele J R,Habersberger J,Braig D,et al.Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation:in vivo proof of a powerful proinflammatory mechanism and a new antiinflammatory strategy[J].Circulation,2014,130(1):35-50.
[14] 李敏,操寄望,罗和生,等.降钙素原在早期评估细菌感染严重程度中的应用[J].中国综合临床,2011,27(4):398-401.
[15] 徐灵玲,曾章锐,郭婧澜,等.血清降钙素原对经皮肾镜碎石术后尿脓毒血症的早期诊断价值[J].山东医药,2016,60(4):49-50.
-
计量
- 文章访问数: 193
- PDF下载数: 1545
- 施引文献: 0
下载: