Abstract: Objective: To explore the clinical efficacy of continuous subcutaneous insulin infusion treatment with insulin bump for patients with gestational diabetes mellitus (GDM).Method: Sixty patients with gestational diabetes mellitus (GDM) were enrolled. GDM patients were randomly divided into continuous subcutaneous insulin infusion group (CSII group=30) and multiple daily subcutaneous injection group (MDSI group=30). The time of blood glucose controlled and the total insulin dosage were recorded. All the 60 cases were followed up for 3 years.Result: The incidence of hypoglycemic reaction in CSII group was lower than that in MDSI group (P<0.05). The incidence of hypoglycemia, Pregnancy complications, fetal morbidity, and prevalence of diabetes within three years was significantly lower than that of MDSI group (P<0.05).Conclusion: CSII with insulin pump can control blood glucose stably and efficiently, and decrease the incidence of hypoglycemia, delivery-related complications and the prevalence rate of diabetes after delivery within 3 years; CSII with insulin pump avoid frequent hypodermic injection and psychological pressure. So it can improve life quality of patients and improve compliance of patients.