氯氮平中毒继发急性肺损伤/急性呼吸窘迫综合征的抢救体会

张伟; 黄家财; 杨杨; 肖章武; 童莲英

doi:10.13201/j.issn.1009-5918.2012.04.014

氯氮平中毒继发急性肺损伤/急性呼吸窘迫综合征的抢救体会

- 南京军区福州总医院急诊科(福州, 350025)

详细信息

通讯作者: 张伟,E-mail:zh-easy@163.com

中图分类号: R595.4

收稿日期: 2011-12-27

Experience of treating patients with acute lung injury/acute respiratory distress syndrome caused by clozapine poison

- Emergency depatrment of Fu Zhou General Hospital, Nanjing Military Command, Fuzhou 350025, China

More Information

Corresponding author: ZHANG Wei, E-mail: zh-easy@163.com

Received Date: 27 December 2011

摘要

摘要: 目的：探讨氯氮平中毒继发急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）有效的治疗方法。方法：总结分析16例氯氮平中毒继发ALI/ARDS患者的临床表现和治疗方法。患者在中毒后6~144 h出现ALI/ARDS表现，予气管插管、机械通气，抗胆碱药物治疗及血液灌流等综合治疗。结果：本组患者均治愈，平均住院时间（14±1.6） d；机械通气时间平均（134±12） h，中毒后（48~96） h意识转清。结论：氯氮平中毒继发的急性肺损伤/急性呼吸窘迫综合征主要与肺水肿、吸入性肺炎及氯氮平对肺组织的直接损伤作用有关。早期进行机械通气联合血液灌流和合理抗胆碱药物的，是治疗重度氯氮平重度并发急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）的有效方法。
- 氯氮平 /
- 中毒 /
- 急性肺损伤/急性呼吸窘迫综合征
Abstract: Objective: To explore the effective therapeutic method of in clozapine poisoning accompany with acute lung injury/acute respiratory distress syndrome patients.Method: Sixteen patients' clinical data of clozapine poisoning accompany with acute lung injury/acute respiratory distress syndrome were collected and analysed. All patients displayed acute lung injury/acute respiratory distress syndrome signs 6~144 hours after clozapine poisoning and were treated with tracheal cannula, mechanical ventilation, Anticholinergics and hemoperfusion et al.Result: All Patients were cured and average stay was 14±1.6 days, average ventilation time was average 134±12 hours, consciousness recovered 48~96 hours after hospitalization.Conclusion: Acute lung injury/acute respiratory distress syndrome caused by clazapine poisoning concerned with pneumonedema, aspiration pneumonia and direct injury of clozapine. Early mechanical ventilation, hemoperfusion and giving anticholinergics reasonably were effective methods of curing severe clozapine poisoning accompany with acute lung injury/acute respiratory distress syndrome.
- clozapine /
- poisoning /
- acute lung injury/acute respiratory distress syndrome

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