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摘要: 脓毒症是指由宿主对感染反应失调所致危及生命的器官功能障碍综合征，其病理机制复杂，最重要的特征是免疫功能紊乱，几乎所有免疫细胞均参与其中。淋巴细胞作为人体重要的免疫细胞，在脓毒症的发生发展和转归中均起着十分重要的作用，近年来对其机制及应用的研究也越来越深入，已成为重要的脓毒症早期筛查、预后评估、免疫监测和调理治疗点。本文旨在通过综述脓毒症中淋巴细胞抑制机制及其研究进展，包括膜受体途径，如负性共刺激分子、细胞因子等，细胞器途径，如线粒体、内质网等，外泌体途径和非编码RNA途径等，以及金属离子介导的铁死亡、铜死亡等，以期为其机制的进一步探索和脓毒症的免疫调理治疗研究提供重要参考。Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Its pathological mechanism is complex, and the most important feature is immune dysfunction, in which almost all immune cells are involved. As an important group of immune cells in our human body, lymphocytes play a very important role in the occurrence, development and outcome of sepsis. In recent years, the research on its mechanism and application has become more and more in-depth, and it has become an important point for early screening, prognosis assessment, immune monitoring and conditioning treatment of sepsis. The aim of this article is to review the mechanisms of lymphocyte suppression in sepsis, including membrane receptor pathways, such as negative costimulatory molecules and cytokines, organelle pathways, such as mitochondria and endoplasmic reticulum, exosome pathways, non-coding RNA pathways, and metal ion-mediated ferroptosis, copper death, etc. This study provides an important reference for the further exploration of its mechanism and the research of immunomodulatory therapy for sepsis.
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Key words:
- sepsis /
- lymphocyte /
- negative costimulatory molecules /
- non-coding RNA /
- exosome
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