心脏缺血再灌注损伤与线粒体质量控制

黄琪惠; 华天凤; 杨旻

doi:10.13201/j.issn.1009-5918.2023.09.001

心脏缺血再灌注损伤与线粒体质量控制

- 1.
  安徽医科大学第二附属医院重症医学二科(合肥，230601)
- 2.
  安徽医科大学第二附属医院心肺复苏与危重病实验室

详细信息

通讯作者: 杨旻，E-mail：yangmin@ahmu.edu.cn

^Δ审校者

中图分类号: R285.5

收稿日期: 2023-07-20

刊出日期: 2023-09-10

Cardiac ischemia-reperfusion injury and mitochondrial quality control

- 1.
  Second Department of Critical Care Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China
- 2.
  Cardiopulmonary Resuscitation and Critical Care Laboratory, the Second Affiliated Hospital of Anhui Medical University

More Information

Corresponding author: YANG Min, E-mail: yangmin@ahmu.edu.cn

Received Date: 20 July 2023

Publish Date: 10 September 2023

摘要

摘要: 心脏缺血再灌注(ischemia-reperfusion，I/R)损伤是心脏疾病中常见并发症，其发生机制复杂且尚未完全阐明。线粒体质量控制(mitochondrial quality control，MQC)是维持心肌细胞正常功能和适应能力的关键过程。MQC系统参与调节线粒体生物合成、线粒体动力学以及自噬环节，保护心肌细胞免受I/R损伤的影响。目前，MQC成为心脏I/R损伤的新型靶向治疗策略。本文通过概述MQC与心脏I/R损伤之间的联系及近期研究机制进展，旨在提供新的思路和研究方向，为心脏疾病的治疗和预防提供理论依据。
- 心脏缺血再灌注损伤 /
- 线粒体质量控制 /
- 线粒体动力学 /
- 线粒体自噬
Abstract: Cardiac ischemia-reperfusion(I/R) injury is a prevalent complication of cardiac diseases, mechanism of which remains intricate and incompletely understood. Mitochondrial quality control(MQC) is a key process in maintaining the normal function and adaptability of cardiomyocytes. The MQC system orchestrates mitochondrial biosynthesis, dynamics, and autophagy, affording protection against I/R injury. At present, MQC has become a new targeted treatment strategy for cardiac I/R injury. By summarizing the relationship between MQC and cardiac I/R injury and the recent research mechanism, this paper aims to provide new ideas and research directions, and provide theoretical basis for the treatment and prevention of heart diseases.
- myocardial ischemia-reperfusion injury /
- mitochondrial quality control /
- mitochondrial dynamics /
- mitochondrial autophagy

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表 1 线粒体裂变的调控分子在心脏I/R中作用

因子	调节分子机制	裂变作用	I/R 作用
DUSP1↓^[22]	JNK/Mff↑	裂变↑	I/R↓
PGAM5↑ ^[23]	Drp^S637去磷酸化↑	裂变↑	I/R↓
KLF4↓^[24]	ROCK1/Drp1/ROS↑	裂变↑	I/R↑
Sirt1↓^[25]	Akt↓/Drp1↑，ROS↑	裂变↑	I/R↑
ZFP36L2↓^[26]	LncRNA PVT1↓	裂变↑	I/R↓
BI1↑^[27]	Syk/Nox2/Drp1 ↓	裂变↓	I/R↓
Hydralazine↑^[28]	Drp1 GTPase↓	裂变↓	I/R↓

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