铁死亡在脓毒症相关脑病中的研究进展

吴晓颖; 李岩

doi:10.13201/j.issn.1009-5918.2023.08.009

铁死亡在脓毒症相关脑病中的研究进展

吴晓颖¹,
李岩^1,Δ, ,

- 同济大学附属上海市第四人民医院急诊科(上海，200434)

详细信息

通讯作者: 李岩，E-mail：181599041@qq.com

^Δ审校者

中图分类号: R459.7

收稿日期: 2023-04-24

刊出日期: 2023-08-10

Progress in ferroptosis in sepsis-associated encephalopathy

WU Xiaoying¹,
LI Yan^1,Δ, ,

- Department of Emergency, Affiliated Shanghai Municipal Fourth People's Hospital, Tongji University, Shanghai, 200434, China

More Information

Corresponding author: LI Yan, E-mail: 181599041@qq.com

Received Date: 24 April 2023

Publish Date: 10 August 2023

摘要

摘要: 综述脓毒症相关脑病(sepsis-associated encephalopathy，SAE)中铁死亡的发生机制及总结现有铁死亡相关药物的应用，并对靶向铁死亡的临床转化应用前景进行展望，为SAE的预防和治疗提供新的理论依据及策略。SAE是一种全身感染引起的认知障碍和急性中枢神经系统功能障碍，是脓毒症的一种严重且常见的并发症，它由缺氧、血脑屏障破坏、神经递质失衡、胶质细胞激活、轴突和神经元缺失引起的炎症。铁死亡发生是因为细胞内铁过载，使铁依赖的脂质代谢异常，氧化还原平衡被破坏，过氧化物蓄积而最终诱发细胞死亡。研究SAE发病机制中的铁死亡，论述抑制铁死亡可通过减少血脑屏障破坏和神经异常、认知障碍来预防SAE。
- 铁死亡 /
- 脓毒症相关脑病 /
- 血脑屏障 /
- 脑功能障碍 /
- 星形胶质细胞
Abstract: To review the mechanism of ferroptosis in sepsis-related encephalopathy(SAE), and summarize the application of existing ferroptosis related drugs, and to prospect the clinical translational application of targeted ferroptosis, in order to provide a new theoretical basis and strategy for the prevention and treatment of SAE.SAE, a cognitive impairment and acute CNS dysfunction due to systemic infection, is a serious and common complication of sepsis, with inflammation caused by hypoxia, blood-brain barrier disruption, neurotransmitter imbalance, glial cell activation, and axonal and neuronal loss. Ferroptosis occurs as a result of intracellular iron overload, which leads to abnormalities in iron-dependent lipid metabolism, disruption of redox homeostasis, and accumulation of peroxides, ultimately inducing cell death.To study ferroptosis in the pathogenesis of SAE and conclude that inhibiting ferroptosis can prevent SAE by reducing blood-brain barrier disruption, neurological abnormalities and cognitive impairment.
- ferroptosis /
- sepsis-related encephalopathy /
- blood-brain barrier /
- brain dysfunction /
- astrocytes

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