Research progress on poor prognosis of neurological function after cardiopulmonary resuscitation
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摘要: 心脏骤停是威胁人类健康的主要原因之一。心脏骤停后患者脑组织因缺血缺氧性损伤及缺血-再灌注损伤, 产生大量氧自由基等有害物质并引起一系列级联反应, 导致血脑屏障破坏、细胞水肿, 最终导致细胞凋亡、神经功能障碍。而自主循环恢复患者的预后和死亡常与脑损伤相关, 对心脏骤停后持续昏迷的患者进行频繁或持续的神经功能监测, 可减少对患者治疗的错误判断, 避免过度医疗或治疗不当, 目前临床上常采用神经系统查体、生物学标志物、神经电生理、神经影像学检查来评估神经系统功能。Abstract: Cardiac arrest is one of the major threats to human health. After cardiac arrest, due to hypoxic ischemia and ischemia-reperfusion injury, the brain tissue of patients produces a large number of harmful substances such as oxygen free radicals and causes a series of cascade reactions, resulting in the destruction of the blood-brain barrier, cell edema, and ultimately cell apoptosis and neurological dysfunction. The prognosis and death of patients with recovery of spontaneous circulation are often related to brain damage. Frequent or continuous neurological monitoring of patients who remain in a coma after cardiac arrest can reduce the misjudgment of patient treatment and avoid excessive medical treatment or inappropriate treatment. Neurological examination, biological markers, neuroelectrophysiology, and neuroimaging are often used clinically to evaluate nervous system function.
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