Value of serum heparin binding protein in predicting acute kidney injury in patients with sepsis
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摘要: 目的:评价血清肝素结合蛋白(HBP)预测脓毒症患者发生急性肾损伤(AKI)的价值。方法:选择2019年5月-2021年5月期间入我院首次确诊的152例脓毒症患者,住院期间73例发生AKI(AKI组),79例未发生AKI(无AKI组)。比较两组血清HBP水平,多因素Logistic回归分析筛选AKI的危险因素。结果:与无AKI组相比,AKI组序贯性器官功能衰竭(SOFA)评分、白血胞计数、C反应蛋白(CRP)、N-端脑利钠肽前体(NT-proBNP)和HBP水平显著升高,而肾小球滤过率(GFR)降低,差异有统计学意义(P<0.05)。Logistic回归分析显示,SOFA评分 ≥ 4、NT-proBNP ≥ 2565 ng/L和HBP ≥ 36.5 pg/mL是AKI发生的独立危险因素(P<0.05)。Spearman检验显示,HBP与SOFA评分和NT-proBNP水平呈现正相关(P<0.05)。受试者工作曲线(ROC)显示,HBP预测AKI的曲线下面积(AUC)为0.865,显著高于NT-proBNP的0.644,但与SOFA评分的0.877相比,差异无统计学意义(P>0.05)。结论:血清HBP升高提示脓毒症患者发生AKI风险增加,是早期预测AKI的重要潜力量化指标。Abstract: Objective:To evaluate the value of serum heparin binding protein(HBP) for predicting acute kidney injury(AKI) in patients with sepsis.Methods:Using prospective research methods, a total of 152 patients with sepsis who was admitted to our hospital from May 2019 to May 2021 were selected for the first time. AKI occurred in 73 cases(AKI group) and 79 cases without AKI(no AKI) during hospitalization. Group). Serum HBP levels of the two groups were compared, and the risk factors of AKI were screened by multivariate Logistic regression analysis.Results:Compared with non-AKI group, sequential organ failure assessment(SOFA) score, white blood cell count, C-reactive protein(CRP), N-terminal pro-brain natriuretic peptide(NT-proBNP) and HBP level were significantly higher, while glomerular filtration rate(GFR) was lower in AKI group(P<0.05). Logistic regression analysis showed that SOFA score ≥ 4, NT-proBNP ≥ 2565 ng/L and HBP ≥ 36.5 pg/mL were independent risk factors for AKI(P<0.05). Spearman test showed that HBP was positively correlated with the SOFA score and NT-proBNP(P<0.05). Receiver operating curve(ROC) showed that area under the curve(AUC) of HBP predicting AKI was 0.865, which was significantly higher than that of NT-proBNP(0.644), while there was no difference compared with the SOFA score(0.877).Conclusion:Higher serum HBP indicates the increased risk of AKI in patients with sepsis, which is an important potential quantitative indicator for early prediction of AKI.
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Key words:
- sepsis /
- acute kidney injury /
- heparin binding protein /
- C-reactive protein
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