急性冠脉综合征患者微粒中miR-126与NLR间的关系及其临床意义

古力斯坦·艾斯卡尔; 布祖克拉·阿布都艾尼; 吐尔孙阿依·依斯米提; 米合拉依·玉素; 穆叶赛·尼加提

doi:10.13201/j.issn.1009-5918.2021.11.004

急性冠脉综合征患者微粒中miR-126与NLR间的关系及其临床意义

- 1. 新疆医科大学研究生院(乌鲁木齐, 830000);
- 2. 新疆医科大学第一附属医院重症医学中心二科;
- 3. 新疆维吾尔自治区人民医院急救中心
基金项目:
新疆维吾尔自治区自然科学基金项目(No:2019D01C104)

详细信息

通讯作者: 穆叶赛·尼加提,E-mail:muyassar11@aliyun.com

中图分类号: R541.4

收稿日期: 2021-08-19

Clinical signifificance and correlation of microRNA-126 expression in microparticlesand the neutrophil-lymphocyte ratio in patients with acute coronary syndrome

- 1 Graduate School of Xinjiang Medical University, Urumqi, 830000, China;
- 2 Department of Intensive Care Center, the First Affiliated Hospital of Xinjiang Medical University;
- 3 Department of Emergency, Xinjiang Uygur Autonomous Region People's Hospital

More Information

Corresponding author: Muyesai·Nejati, E-mail: muyassar11@aliyun.com

Received Date: 19 August 2021

摘要

摘要: 目的:探讨急性冠脉综合征(ACS)患者微粒中miR-126与中性粒细胞/淋巴细胞比值(NLR)间的关系及其临床意义。方法:选取2019年1月-2019年10月期间住院确诊为ACS的患者44例(病例组),其中急性心肌梗死患者22例(AMI组),不稳定性心绞痛患者22例(UA组);另取冠脉造影排除冠心病的对照组15例。收集上述患者冠脉血标本,利用流式细胞仪检测内皮细胞源微粒,用qRT-PCR法检测其中的miR-126表达水平。结果:AMI组、UA组及对照组AST、cTnT、EF%水平比较,均差异有统计学意义(P<0.05);UA组miR-126表达水平明显高于AMI组和对照组;AMI组NLR水平明显高于UA组和对照组。多元Logistic回归结果显示,miR-126(OR=0.000 454,95%CI:2.5594E-7~0.807)与ACS的发生独立相关。miR-126与NLR对ACS的诊断价值通过ROC工作曲线进行分析,结果显示miR-126的曲线下面积AUC=0.439 (95%CI:0.285~0.592,P=0.481); NLR的曲线下面积AUC=0.721(95%CI:0.587~0.855,P=0.011),miR-126与NLR联合变量曲线下面积AUC=0.736,(95%CI:0.603~0.870,P=0.007)。Pearson相关性分析显示:ACS患者Genisi评分与miR-126表达呈负相关(r=-0.303,P=0.045);Spearman相关性分析显示miR-126与NLR呈负相关(r=-0189,P=0.045)。结论:内皮细胞源微粒中miR-126表达水平与ACS发生独立相关;miR-126与ACS患者冠脉狭窄程度存在相关性;同时,miR-126及NLR对ACS具有诊断价值。
- 急性冠脉综合征 /
- 内皮细胞微粒 /
- miR-126 /
- 中性粒细胞/淋巴细胞比值
Abstract: Objective:To explore the Clinical signifificance and correlation of microRNA-126(miR-126) expression in microparticlesand neutrophil-lymphocyte ratio(NLR) in patients with acute coronary syndrome(ACS).Methods:A selection of 44 patients(case group) who were hospitalized with ACS in the Department of Cardiology of the People's Hospital of the Autonomous Region from January 2019 to October 2019, including 22 patients with acute myocardial infarction(AMI) and 22 patients with unstable angina(UA) Cases, and 15 cases in the control group that excluded coronary heart disease by coronary angiography. Collect the coronary blood samples of the above patients, use flow cytometry to detect endothelial cell-derived particles, and use qRT-PCR to detect the expression level of miR-126.Results:Among the AMI, UA and control groups, the levels of AST, cTnT, and EF% were different(P<0.05); the expression level of miR-126 in the UA group was significantly higher than that of the AMI group and the control group; the NLR level of the AMI group was significantly higher than that of the UA group and the control group. Control group. The results of multiple Logistic regression showed that miR-126(OR=0.000454, 95%CI:2.5594 E-7-0.807)was independently related to the occurrence of ACS. The diagnostic value of miR-126 and NLR for ACS was analyzed by ROC working curve:the results showed that the area under the curve of miR-126 was AUC=0.439(95%CI:0.285-0.592, P=0.481).The area under the curve of NLR was AUC=0.721(95%CI:0.587-0.855, P=0.011), and the area under the curve of the joint variables of miR-126 and NLR was AUC=0.736(95%CI:0.603-0.870, P=0.007).Pearson correlation analysis showed that Genisi score of ACS patients was negatively correlated with miR-126 expression(r=-0.303,P=0.045); Spearman correlation analysis showed that miR-126(r=-0189, P=0.045) was negatively correlated with NLR.Conclusion:The expression level of miR-126 in endothelial cell-derived microparticles is independently correlated with the occurrence of acute myocardial infarction; miR-126 is correlated with the degree of coronary stenosis in patients with ACS; at the same time, miR-126 and NLR have predictive value in the diagnosis of ACS.
- acute coronary syndrome /
- endothelial cell microparticles /
- miR-126 /
- NLR

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