APACHEⅡ评分联合血清RBP和Cys-C在ICU脓毒症性急性肾损伤患者中的评估价值

武道荣; 方磊; 李睿; 王鹏; 冯开俊; 宋秋鸣

doi:10.13201/j.issn.1009-5918.2021.08.011

APACHEⅡ评分联合血清RBP和Cys-C在ICU脓毒症性急性肾损伤患者中的评估价值

- 1. 安徽医科大学第三临床学院(合肥市第三人民医院)重症医学科(合肥, 230022);
- 2. 安徽医科大学第一附属医院干部呼吸与危重症医学科
基金项目:
安徽省自然科学基金项目(No:1908085QH311)

安徽省合肥市卫建委2020年新冠疫情防控科研项目基金(No:Hwk2020yb007)

合肥市第三人民医院课题基金(No:SYKY201903)

详细信息

通讯作者: 宋秋鸣,E-mail:songqm196883@163.com

中图分类号: R459.7

收稿日期: 2021-05-23

Evaluation value of APACHEⅡ combined with RBP and Cys-C in patients of septic acute kidney injury in ICU

- 1. Department of Intensive Care, Third Clinical College of Anhui Medical University, the Third People's Hospital of Heifei, Heifei, 230022, China;
- 2. Department of Cadre Respiratory and Critical Care Medicine, the Affiliated Hospital of Anhui Medical University

More Information

Corresponding author: SONG Qiuming, E-mail: songqm196883@163.com

Received Date: 23 May 2021

摘要

- 脓毒症 /
- 急性肾损伤 /
- 急性生理与慢性健康评分 /
- 视黄醇结合蛋白 /
- 胱抑素C
Abstract: Objective: To investigate the value of acute physiology and chronic health score(APACHEⅡ) combined with retinol binding protein(RBP) and cystatin C(Cys-C) levels in evaluating the condition and prognosis of patients with septic acute kidney injury(SAKI) in ICU.Methods: A retrospective analysis was conducted to analyze, According to the clinical data of 102 patients with sepsis in the ICU from April 2017 to March 2021.They were divided into SAKI group and control group according to whether they were complicated with acute kidney injury(AKI). APACHEⅡ score and serum creatinine(SCr), RBP, and Cys-C level were compared between the two groups. The patients were divided into survival group and death group according to their 28 day survival. The APACHEⅡ score and SCr, RBP, and Cys-C level were compared between the two groups. Receiver operating characteristic(ROC) curve was used to analyze the value of APACHEⅡ score combined with RBP and Cys-C in assessing the occurrence and prognosis of SAKI patients, and the correlation between APACHEⅡ score, SCr, RBP and Cys-C was analyzed.Results: The APACHEⅡ score, SCr, RBP, Cys-C in SAKI group were higher than those in control group(P<0.05); The APACHEⅡ score and SCr, RBP, Cys-C in death group were higher than those in survival group(P<0.05); The area under the curve(AUC) of APACHEⅡ score combined with RBP and Cys-C in assessing the occurrence of SAKI in patients with sepsis was larger than that of APACHEⅡ score and RBP and Cys-C analyzed alone(P<0.05); patients with APACHEⅡ score≥23.5, RBP≥77.5 mg/L and Cys-C≥1.95 mg/L were prone to SAKI; The AUC of APACHEⅡ score combined with SCr, RBP and Cys-C in evaluating the prognosis of patients with sepsis was higher than that of APACHEⅡ score and single detection of SCr, RBP and Cys-C(P<0.05); patients with APACHEⅡ score≥21.5, SCr≥81.5μmol/L, RBP≥75.5 mg/L and Cys-C≥1.55 mg/L had a poor prognosis(P<0.05); APACHEⅡ score was positively correlated with SCr, RBP and cys-c.Conclusion: APACHEⅡ score combined with serum RBP and Cys-C has high value in evaluating the occurrence and prognosis of SAKI in patients with sepsis, which is worthy of clinical promotion.
- sepsis /
- acute kidney injury /
- acute physiology and chronic health score /
- retinol binding protein /
- cystatin C

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