新鲜冷冻血浆治疗竹叶青蛇咬伤致PT或APTT延长的临床疗效评价

张聪聪; 曾仲意; 黄培颖

doi:10.13201/j.issn.1009-5918.2021.06.006

新鲜冷冻血浆治疗竹叶青蛇咬伤致PT或APTT延长的临床疗效评价

- 1. 深圳市中医院急诊科(广东深圳,518033);
- 2. 广州中医药大学第四临床医学院
基金项目:
广东省医学科研基金(No:B2020135)

详细信息

通讯作者: 曾仲意,E-mail:zeng-zhongyi@163.com

中图分类号: R646

收稿日期: 2021-02-27

Clinical evaluation of fresh frozen plasma in the treatment of Trimeresurus Stejneger

- 1. Department of Emergency, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, 518033, China;
- 2. The Forth Clinical Medical School of GuangZhou University of Chinese Medicine

More Information

Corresponding author: CENG Zhongyi, E-mail: zeng-zhongyi@163.com

Received Date: 27 February 2021

摘要

摘要: 目的:评价新鲜冷冻血浆治疗竹叶青蛇咬伤的临床疗效。方法:通过回顾性队列研究,收集2011年1月1日24时-2018年1月1日24时期间竹叶青蛇咬伤致PT或APTT>正常值1.5倍的316例患者,根据是否应用血浆分为治疗组及对照组,通过单因素组间对照及多重线性回归探究是否应用血浆对于患者在院期间病情严重程度、PT或APTT恢复时间、住院时间及治疗总费用的影响。结果:单因素分析显示,应用血浆明显降低了患者在院期间病情的严重程度,缩短PT或APTT的恢复时间,但治疗费用明显高于对照组。多重线性回归显示,应用血浆能有效降低患者在院期间病情的严重程度,但治疗总费用高于未应用血浆的患者。此外,有基础病及到院时中毒情况较重的患者,其在院病情严重程度较高,而应用抗蛇毒血清能明显降低PT或APTT的恢复时间。结论:对于PT或APTT延长>正常值1.5倍的竹叶青蛇咬伤患者,可应用新鲜冷冻血浆进行治疗。血浆能降低患者在院期间的病情严重程度,一定程度上缩短PT或APTT的恢复时间,但对于患者的住院时间未见明显缩短,且费用相对较高。
- 竹叶青蛇咬伤 /
- 新鲜冷冻血浆 /
- 临床疗效
Abstract: Objective: To evaluate the clinical efficacy of fresh frozen plasma in the treatment of Trimeresurus Stejneger.Methods: A retrospective cohort study was conducted, clinical data of 316 patients with PT or APTT>1.5 times the normal value caused by snake bite from 24: 00 on January 1, 2011 to 24: 00 on January 1, 2018 were collected. According to whether plasma was used, they were divided into treatment group and control group. Univariate inter group control and multiple linear regression were used to explore the effects of plasma on the severity of disease, recovery time of PT or APTT, hospitalization time and the total cost of treatment.Results: The single factor analysis showed that the application of plasma significantly reduced the severity of patients' condition during hospital, shortened the recovery time of PT or APTT, but the treatment cost was significantly higher than that of the control group. Multiple linear regression showed that the use of plasma can effectively reduce the severity of patients' condition during hospital, but the total cost of treatment was higher than that of patients without plasma. In addition, the patients with basic diseases and severe poisoning at the time of admission have higher severity of illness in the hospital, and the application of antivenom serum can significantly reduce the recovery time of PT or APTT.Conclusion: Fresh frozen plasma can be used for the bite of Trimeresurus Stejneger with PT or APTT prolonging>1.5 times normal value. Plasma can reduce the severity of the patient's condition during hospitalization, shorten the recovery time of PT or APTT to a certain extent, but the hospitalization time of the patient is not significantly shortened, and the cost of treatment is relatively high.
- Trimeresurus Stejnegeri bite /
- fresh frozen plasma /
- clinical efficacy

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