运动性猝死与肾上腺功能不全的关系及防治研究进展

李茜茜; 郭建军; 郭伟; 赵志刚

doi:10.13201/j.issn.1009-5918.2021.05.014

运动性猝死与肾上腺功能不全的关系及防治研究进展

- 1. 首都医科大学附属北京胸科医院药学部(北京, 101149);
- 2. 首都体育学院体医融合创新研究中心;
- 3. 首都医科大学附属北京天坛医院急诊科
基金项目:
中国科协科创项目国家级体医融合体育健康团助力地方大健康产业创新发展(No:ZLGC202001-35)

详细信息

通讯作者: 赵志刚,E-mail:1022zzg@sina.com

中图分类号: R586

收稿日期: 2021-02-19

Research progress on the relationship between exercise sudden death and adrenal insufficiency and its prevention and treatment

More Information

Corresponding author: , E-mail: 1022zzg@sina.com

Received Date: 19 February 2021

摘要

- 肾上腺皮质功能不全 /
- 肾上腺危象 /
- 猝死 /
- 运动
Abstract: Adrenal insufficiency(AI) is an endocrine dysfunction disease caused by primary or hypothalamic-pituitary-adrenal axis injury. Although the incidence is low, it will cause adrenal crisis(AC) and life-threatening if neglected. Exercise sudden death is a great threat to athletes and sports enthusiasts. Although the incidence is low, the cause and mechanism of exercise sudden death are not clear enough, which is a great obstacle to prevention and treatment. Athletes and sports enthusiasts have a high frequency of glucocorticoids(GC) due to sports injuries and professionalcharacteristic. Then it likely occurs that either the use of GC or other reasons inhibit the adrenal cortex and lead to an increase in the incidence of AI and AC. To explore the relationship between AI or AC and sudden exercise death, this paper proposes assumptions that the mechanism of AC leading to sudden exercise death was related to electrolyte disturbance, increased secretion of inflammatory factors and vagal nerve excitation through literature research. Whether AI patients need to supplement GC under stress conditions such as exercise is still controversial. At present, it is only recommended to supplement the stress dose GC before and during exercise for a long time. However, the fairness of GC use in athletes still needs further discussion. Improving the education level of patients on the rational use of GC, strengthening the cognitive education of medical workers AC\\AI and equipping sports venues with external defibrillators are important measures to prevent sudden exercise death.
- adrenal insufficiency /
- adrenal crisis /
- sudden death /
- exercise

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