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Abstract: To explore the clinical characteristics of nervous system damage caused by nitrous oxide abuse, and to improve clinicians' understanding of this disease. The data of a case of nervous system damage caused by nitrous oxide abuse were analyzed and combined with domestic and foreign literatures. The patient suffered from nervous system damage caused by long-term and large amount of nitrous oxide inhalation, which was manifested as the spinal cord damage of subacute combined degeneration, peripheral neuropathy mainly caused by axonal damage, and accompanied by hyperhomocysteinemia. MRI showed that the horizontal spinal cord signal of cervical 2-5 vertebral body was uneven, longitudinal long T2 signal shadow was seen on the dorsal side, and "enhanced inverted V" sign(rabbit ear sign) on the dorsal side of spinal cord was seen on the axial position. The number of patients with nervous system damage caused by nitrous oxide poisoning is increasing. Clinicians should improve their understanding of this kind of disease, and then make early diagnosis and treatment so as to improve the prognosis of patients.
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Key words:
- nitrous oxide /
- subacute combined degeneration /
- vitamin B12 /
- homocysteine
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