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Key words:
- sepsis /
- preventing /
- infection /
- cytokines /
- organ function
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[1] Singer M,Deutschman CS,Seymour CW,et al.The third International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3)[J].JAMA,2016,315(8):801-810.
[2] Fleischmann C,Scherag A,Adhikari NK,et al.Assessment of Global Incidence and Mortality of Hospital-treated Sepsis.Current Estimates and Limitations[J].Am J Respir Crit Care Med,2016,193(3):259-272.
[3] Adhikari NK,Fowler RA,Bhagwanjee S,et al.Critical care and the global burden of critical illness in adults[J].Lancet,2010,376(9749):1339-1346.
[4] Xie J,Wang H,Kang Y,et al.The Epidemiology of Sepsis in Chinese ICUs:A National Cross-Sectional Survey[J].Crit Care Med,2020,48(3):e209-e218.
[5] Kaukonen KM,Bailey M,Suzuki S,et al.Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand,2000-2012[J].JAMA,2014,311(13):1308.
[6] Martin GS,Mannino DM,Eaton S,et al.The Epidemiology of Sepsis in the United States from 1979 through 2000[J].New Engl J Med,2003,348(16):1546-1554.
[7] Weng L,Zeng XY,Yin P,et al.Sepsis-related mortality in China:a descriptive analysis[J].Intensive Care Med,2018,44(7):1071-1080.
[8] 梁建峰,李智勇,董海山,等.影响ICU脓毒症病人预后的多因素分析[J].中国急救医学,2018,39(1):46-52.
[9] 孙树印,刘云海,陈玉国.脓毒症的治疗进展[J].医学综述,2013,19(3):499-501.
[10] Grande E,Grippo F,Frova L,et al.The increase of sepsis-related mortality in Italy:a nationwide study,2003-2015[J].Eur J Clin Microbiol Infect Dis,2019,38(9):1701-1708.
[11] Reinhart K,Daniels R,Kissoon N,et al.Recognizing Sepsis as a Global Health Priority—A WHO Resolution[J].New Engl J Med,2017,377(5):414-417..
[12] 沈洪,刘中民.急诊与灾难医学[M].2版.北京:人民卫生出版社,2013.
[13] 中国医药教育协会感染疾病专业委员会.感染相关生物标志物临床意义解读专家共识[J].中华结核和呼吸杂志,2017,40(4):243-257.
[14] 降钙素原急诊临床应用专家共识组.降钙素原(PCT)急诊临床应用的专家共识[J].中华急诊医学杂志,2012,21(9):944-951.
[15] 徐冬梅,季孝,周雪芬,等.白细胞介素-6、血清淀粉样A蛋白、唾液酸、HBP在发热患者中的诊断价值[J].中国卫生检验杂志,2019,29(24):3027-3209.
[16] 吴智慧,郑洁,黄伟,等.血清白细胞介素-6对感染相关脓毒症患者病情的评估效果[J].中华医院感染学杂志,2019,29(17):2580-2583.
[17] Johansson J,Brattstrom O,Sjoberg F,et al.Heparin-binding protein(HBP):An early marker of respiratory failure after trauma?[J].Acta Anaesthesiol Scand,2013,57(5):580-586.
[18] 邱艳花,杨录波,邱淑妍,等.肝素结合蛋白在脓毒症诊断及分级中的应用[J].深圳中西医结合杂志,2018,28(20):58-59.
[19] Cheng B,Xie G,Yao S,et al.Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China[J].Crit Care Med,2007,35:2538-2546.
[20] Du B,An Y,Kang Y,et al.Characteristics of Critically Ill Patients in ICUs in Mainland China[J].Crit Care Med,2013,41(1):84-92.
[21] Zhou JF,Qian CY,Zhao MY,et al.Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China[J].Plos One,2014,9(9):e107181.
[22] He XL,Liao XL,Xie ZC,et al.Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients[J].Biomed Res Int,2016,2016:4213712..
[23] Walkey AJ,Wiener RS,Lindenauer PK.Utilization Patterns and Outcomes Associated With Central Venous Catheter in Septic Shock:A Population-Based Study[J].Crit Care Med,2013,41(6):1450-1457.
[24] Annane D,Bellissant E,Cavaillon JM.Septic shock[J].Lancet,2005,365(9453):63-78.
[25] Vincent JL,Sakr Y,Sprung CL,et al.Sepsis in European intensive care units:Results of the SOAP study[J].Crit Care Med,2006,34(2):344-353.
[26] Ramachandran G.Gram-positive and gram-negative bacterial toxins in sepsis[J].Virulence,2014,5(1):213-218.
[27] Angus DC,Kelley MA,Schmitz RJ,et al.Caring for the critically ill patient.Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease:can we meet the requirements of an aging population[J].JAMA,2000,284(21):2762.
[28] 刘毅,宋诗铎,王洪霞.ICU医院感染相关脓毒症病原菌分布及耐药性分析[J].中华医院感染学杂志,2010,20(3):131-133.
[29] Huang C,Wang Y,Li X,et al.Clinical features of patients infected with 2019 novel coronavirus in Wuhan,China[J].Lancet,2020,395(10223):497-506.
[30] Ziegler EJ,Fisher CJ,Sprung CL,et al.Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin-A Randomized,Double-Blind,Placebo-Controlled Trial[J].N Engl J Med,1991,324(7):429-436.
[31] Vincent JL,Bihari DJ,Suter PM,et al.The Prevalence of Nosocomial Infection in Intensive Care Units in Europe:Results of the European Prevalence of Infection in Intensive Care(EPIC)Study[J].JAMA,1995,274(8):639-644.
[32] Vincent JL,Moreno R,Takala J,et al.The SOFA(Sepsis-related Organ Failure Assessment)score to describe organ dysfunction/failure[J].Intensive Care Med,1996,22(7):707-710.
[33] Ferreira FL,Bota DP,Bross A,et al.Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients[J].JAMA,2001,286(14):1754.
[34] 国医师协会急诊医师分会,中国研究型医院学会休克与脓毒症专业委员会 .中国脓毒症/脓毒症休克急诊治疗指南(2018)[J].临床急诊杂志,2018,19(9):567-588.
[35] Freund Y,Lemachatti N,Krastinova E,et al.Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department[J].JAMA,2017,317(3):301.
[36] Fernando SM,Alexandre T,Monica T,et al.Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection[J].Ann Intern Med,2018,168(4):266.
[37] Haydar S,Spanier M,Weems P,et al.Comparison of qSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis[J].Am J Emerg Med,2017,35(11):1730.
[38] Hwang SY,Jo IJ,Lee SU,et al.Low Accuracy of Positive qSOFA Criteria for Predicting 28-Day Mortality in Critically Ill Septic Patients During the Early Period After Emergency Department Presentation[J].Ann Intern Med,2018,71(1):1.
[39] Churpek MM,Snyder A,Han X,et al.Quick Sepsis-related Organ Failure Assessment,Systemic Inflammatory Response Syndrome,and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit[J].Am J Resp Crit Care,2017,195(7):906.
[40] Goulden R,Hoyle MC,Monis J,et al.qSOFA,SIRS and NEWS for predicting inhospital mortality and ICU admission in emergency admissions treated as sepsis[J].Emerg Med J,2018,35(6):345.
[41] Royal College of Physician.National Early Warning Score(NEWS):standardising the assessment of acute-illness severity in the NHS.Report of a working party[R].London:Royal College of Physicians,2012.
[42] 梁镰静,秦溱,胡海,等.改良早期预警评分系统对老年休克病人预后的预测价值[J].临床急诊杂志,2017,18(3):53-57,61.
[43] 朱逸敏,张文宏.二代测序在脓毒血症患者病原学诊断中的应用[J].微生物与感染,2018,13(2):97-101.
[44] Gilbert DN,Chambers HF,Ellopoulos GM,et al.The Sanford Guide to Antimicrobial Therapy 2018[M].48版.北京:中国协和医科大学出版社,2019.
[45] Jekarl DW,Kim KS,Lee S,et al.Cytokine and molecular networks in sepsis cases:a network biology approach[J].Eur Cytokine Netw,2018,29(3):103-111.
[46] 夏照帆,伍国胜.浅谈细胞因子在脓毒症中的作用及临床应用现状[J].中华烧伤杂志,2019,35(1):3-7.
[47] 姚咏明,张艳敏.脓毒症发病机制最新认识[J].医学研究生学报,2017,30(7):678-683.
[48] Batzofin BM,Sprung CL,Weiss YG.The use of steroids in the treatment of severe sepsis and septic shock[J].Best Pract Res Clin Endocrinol Metab,2011,25(5):735-743.
[49] Kalil AC,Sun J.Low-dose steroids for septic shock and severe sepsis:the use of Bayesian statistics to resolve clinical trial controversies[J].Intens Care Med,2011,37(3):420-429.
[50] Heming N,Sivanandamoorthy S,Meng P,et al.Immune effects of corticosteroids in sepsis[J].Front Immunol,2018,9:1736.
[51] Park KH,Lee KH,Kim H.The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock[J].J Korean Med Sci,2010,25(1):128.
[52] 常秀娟,张帅,江益平,等.从细胞因子风暴探讨热毒宁注射液抗大鼠急性肺损伤作用机制[J].中草药,2015,46(2):236-239.
[53] Tang LP,Xiao W,Li YF,et al.Anti-inflammatory effects of Reduning Injection on lipopolysaccharide-induced acute lung injury of rats[J].Chin J Integr Med,2014,20(8):591-599.
[54] 王开富,萧伟,王振中,等.热毒宁注射液的解热抗炎作用及其机制[J].中国医院药学杂志,2013,33(23):1918-1922.
[55] 王素云,李刚.热毒宁注射液在儿科临床的应用[J].环球中医药,2015,8(S1):110.
[56] 欧娅,黄耀星,苏伟,等.血必净注射液对SAP大鼠TLR4信号通路介导肠黏膜屏障功能障碍的影响[J].广州医药,2019,50(3):1-5.
[57] 卢文静,李伟哲,王鑫,等.百草枯中毒大鼠肺组织中TNF-α、TGF-β1、IL-13的表达及血必净注射液干预的作用[J].现代中西医结合杂志,2019,28(32):3567-3571.
[58] 孙梦杰,屠亚茹,欧阳慧子,等.血必净注射液及其药代标示物对脓毒症大鼠炎性因子TNF-α、IL-1、IL-6、IL-8和IL-10表达的影响[J].天津中医药大学学报,2018,37(1):13-15.
[59] 赵士兵,何先弟,汪华学,等.脓毒症大鼠血清高迁移率族蛋白B1的变化规律及血必净的干预效果研究[J].中国中西医结合杂志,2014,34(6):739-744.
[60] Wang Q,Wu X,Tong X,et al.Xuebijing ameliorates sepsis-induced lung injury by downregulating HMGB1 and RAGE expressions in mice[J].Evid Based Complement Alternat Med,2015,2015:860259.
[61] 赵露茜,朱国栋,张靖轩,等.脓毒症大鼠IL-6、TNF-α、TH水平和D2活性变化及血必净注射液的干预研究[J].实用医学杂志,2018,34(16):2670-2674.
[62] Li CY,Wang P,Zhang L,et al.Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis:A meta-analysis of randomized controlled trials[J].J Ethnopharmacol,2018,224:512-521.
[63] 王硕,李丽娜,齐文升,等.炎症反应调控与脓毒症防治方法进展[J].现代仪器与医疗,2018,24(5):30-32.
[64] Mathias B,Delmas AL,Ozrazgat-Baslanti T,et al.Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock[J].Ann Surg,2017,265(4):827.
[65] Shankar-Hari M,Harrison DA,Rubenfeld GD,et al.Epidemiology of sepsis and septic shock in critical care units:comparison between sepsis2 and sepsis3 populations using a national critical care database[J].Br J Anaesth,2017,119(4):626-636.
[66] Thomas H.Sepsis:bile acids promote inflammation in cholestasis-associated sepsis[J].Nat Rev Gastroenterol Hepatol,2017,14(6):324-325.
[67] 黄鑫波,刘端绘.脓毒症免疫抑制监测与免疫治疗的研究进展[J].广西医学,2020.42(4):486-490.
[68] Rodelo JR,De la Rosa G,Valencia ML,et al.D-dimer is a significant prognostic factor in patients with suspected infection and sepsis[J].Am J Emerg Med,2012,30(9):1991-1999.
[69] 沈国锋,李响,倪金迪,等.低分子肝素治疗对ICU脓毒症患者急性肺损伤/急性呼吸窘迫综合征的影响[J].中国急救医学,2016,36(12):1130-1132.
[70] 戴琳琳.低分子肝素抗凝治疗对ICU脓毒症患者的效果观察[J].医学理论与实践,2019,32(1):51-52.
[71] Nguyen HB,Rivers EP,Knoblich BP,et al.Early lactate clearance is associated with improved outcome in severe sepsis and septic shock[J].Crit Care Med,2004,32(8):1637-1642.
[72] Marecaux G,Pinsky MR,Dupont E,et al.Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock[J].Intensive Care Med,1996,22(5):404-408.
[73] 中华医学会急诊医学分会,中国医师协会急诊医师分会,中国人民解放军急救医学专业委员会,等.脓毒症液体治疗急诊专家共识[J].中华急诊医学杂志,2018,27(1):30-38.
[74] Karthik R,Patrick N,Ryan K.What is the ideal crystalloid?[J].Curr Opin Crit Care,2015,21(4):309-314.
[75] Demling R,Lalonde C,Saldinger P,et al.Multiple-organ dysfunction in the surgical patient:pathophysiology,prevention,and treatment.[J].Curr Probl Surg,1993,30(4):345.
[76] 张艺平,韩鹏.中药抗内毒素研究新进展[J].中国中西医结合急救杂志,2001,8(2):122.
[77] 余丹凤,翁银燕,徐建,等.大承气汤对行机械通气严重脓毒症患者炎症反应和免疫调节功能的影响[J].中国中医药科技,2011,18(3):181-182.
[78] 金铭,李春盛.血必净注射液对重症脓毒症凝血功能及预后影响的研究[J].中华内科杂志,2009,48(3):235-236.
[79] Yin Q,Li C.Treatment Effects of Xuebijing Injection in Severe Septic Patients With Disseminated Intravascular Coagulation[J].Evid Based Complement Alternat Med,2014,2014:949254.
[80] 郭昌星,杨兴易,林兆奋,等.生脉注射液对全身炎症反应综合征患者血浆血管活性介质影响的临床观察[J].中国中西医结合急救杂志,2004,11(4):239-241.
[81] 陈德昌,景炳文,杨兴易,等.大黄对危重症患者胃肠道的保护作用[J].中华危重病急救医学,2000,12(2):87-89.
[82] 陈德昌,马丽琼,刘绍泽,等.大黄对脓毒症大鼠肠道细菌及其移位的影响[J].中华危重病急救医学,2009,21(1):17-20.
[83] 陈德昌,杨兴易,景炳文,等.大黄对危重病患者多器官功能衰竭综合征的防治研究[J].中华急诊医学杂志,2004,13(2):103-106.
[84] 黄增峰,陈德昌,陈如康,等.人参皂甙对烫伤脓毒症大鼠细胞免疫功能的影响[J].中国中西医结合急救杂志,2006,13(4):225-227.
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