Effects of Nesiritide on cardiac function and serum interleukin-6 in patients with heart failure after cardiopulmonary resuscitation
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摘要: 目的:探讨新活素对心肺复苏(CPR)后心力衰竭患者心功能及血清IL-6的影响。方法:将96例呼吸心跳骤停心肺复苏成功后发生心力衰竭的患者随机分为对照组和观察组。对照组患者给予临床常规心力衰竭治疗,而观察组患者在常规治疗的同时给予静脉滴注新活素治疗。比较观察组与对照组患者的治疗总有效率、心功能指标和血清IL-6水平。结果:观察组患者治疗总有效率91.66%,明显高于对照组的72.92%(χ2=6.14,P=0.03);治疗后,观察组的CO、CI、SV及LVEF均明显高于对照组(P<0.01),血清IL-6水平明显低于对照组(t=12.18,P<0.01)。结论:心肺复苏后心力衰竭患者应用新活素,可降低血清IL-6水平,对改善心脏结构及功能疗效显著,可改善患者预后。Abstract: Objective:To investigate the effects of Nesiritide on cardiac function and serum interleukin-6 in patients with heart failure after cardiopulmonary resuscitation. Method:Ninety-six patients with heart failure after successful cardiopulmonary resuscitation were randomly divided into control group and observation group with 48 cases in each group. Patients in the control groupwere given conventional heart failure treatment,while patients in the observation group were treated with intravenous drip of Nesiritide. The total effective rate was compared between the two groups, and the cardiac function indexes and serum IL-6 levels were compared before and after treatment. Result:The total effective rate was 91.66% in the observation group, which was significantly higher than that of 72.92% in the control group(χ2=6.14, P=0.03). After treatment, the levels of LVEF, SV, CI and CO in the observation group were significantly higher than those in the control group(P<0.01), and the levels of IL-6 in the serum were significantly lower than those in the control group(t=12.18, P<0.01).Conclusion:The clinical effect of Nesiritide on heart failure after CPR is remarkable. It can effectively improve the structure and function of heart, reduce the level of serum IL-6 and improve the prognosis of patients.
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Key words:
- Nesiritide /
- cardiopulmonary resuscitation /
- heart failure /
- cardiac function /
- interleukin-6
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