白蛋白在脓毒症患者液体管理中的应用进展

孟焕新; 马洪芳; 王金荣; 崔朝勃

doi:10.13201/j.issn.1009-5918.2019.09.019

白蛋白在脓毒症患者液体管理中的应用进展

- 哈励逊国际和平医院重症医学科(河北衡水,053000)
基金项目:
2016年河北省省级科技计划项目(No:162777279)

详细信息

通讯作者: 王金荣,E-mail:iamwjr306@163.com

中图分类号: R737.9

收稿日期: 2019-05-26

Progress of albumin in fluid management for sepsis patients

More Information

Corresponding author: , E-mail: iamwjr306@163.com

Received Date: 26 May 2019

摘要

- 白蛋白 /
- 胶体 /
- 晶体 /
- 脓毒症 /
- 液体复苏
Abstract: Fluid administration is a key intervention in hemodynamic resuscitation. Timely expansion(or restoration) of plasma volume may prevent tissue hypoxia and help to preserve organ function in septic shock. Ideally, colloids can remain in the intravascular space for longer periods than do crystalloids thereby with better effects in decreasing leakage through the endothelium in conditions with increased permeability such as sepsis and/or supplying external losses in conditions such as hemorrhage and burns. Albumin has pleiotropic physiological activities including antioxidant effects and positive effects on vessel wall integrity. Its administration facilitates achievements of a negative fluid balance in hypoalbuminemia and in conditions associated with edema. Fluid resuscitation with human albumin is less likely to cause nephrotoxicity than with artificial colloids, and albumin infusion has the potential to preserve renal function in critically ill patients.
- albumin /
- colloids /
- crystalloids /
- sepsis /
- fluid resuscitation

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