Abstract: Objective: To study the changes of serum il-33 and sST2 in trauma patients and their correlation with CRP and injury degree score(ISS). Method: Selected from January 2016 to December 2016 in our hospital for treatment of 60 patients with trauma were observed object as A group, and have A medical examination in our hospital from 50 healthy persons as observation group B object, compare two groups of different time points, the change of the serum IL-33, sST2, CRP, and analyze the serum IL-33 and the correlation between the sST2, CRP, ISS. Result: Serum il-33 level in group A was higher than that in group B at different time points(P<0.05). At 1 d after trauma, it reached the equivalent level, which was significantly different from group B(P<0.05). The sST2 level of group A was higher than that of group B at 4 h~3 d after trauma(P<0.05). SST2 level in group A was slightly higher than that in group B at 5~7 d after trauma, but there was no statistical difference(P>0.05). CRP levels of group A at different time points were higher than that of group B(P<0.05). The post-traumatic 3 d reached a peak value, which was significantly higher than that of group B(P<0.05). There was a positive correlation between serum il-33 level and CRP level 4 h~7 d after trauma(r=0.351, P<0.05). There was a positive correlation between sST2 level and CRP level(r=0.382, P<0.05). 4 h~1 d after trauma, there was a positive correlation between serum il-33 level and ISS score(r=0.367, P<0.05).Conclusion: Trauma can lead to the release of serum il-33 and sST2, and the release level is closely related to the CRP and ISS scores, so it should be paid attention to in clinical practice.