The detection and significance of serum chemerin,omentin-1,APN,IL-1 beta and TNF-alpha in children with Kawasaki disease
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摘要: 目的:探讨川崎病 (KD) 患儿血清脂肪因子chemerin、网膜素-1 (omentin-1)、脂联素 (APN)、白细胞介素1β (IL-1β)、肿瘤坏死因子α (TNF-α) 水平检测及其意义。方法:选取2015-06-2018-06期间收治的KD患儿98例作为KD组, 同期选取体检中心健康儿童30例作为健康组, 检测所有儿童血清chemerin、omentin-1、APN、IL-1β、TNF-α水平并分析其与意义。结果:KD组血清chemerin、IL-1β、TNF-α水平明显高于健康组, KD组血清omentin-1、APN水平明显低于健康组, 差异有统计学意义 (P＜0.05);KD组中, 急性期患儿血清chemerin、IL-1β、TNF-α水平明显高于亚急性期患儿, 急性期患儿血清omentin-1、APN水平明显低于亚急性期患儿, 冠脉损伤 (CAL) 患儿血清chemerin、IL-1β、TNF-α水平明显高于无CAL患儿, CAL患儿血清omentin-1、APN水平明显低于无CAL患儿, 差异有统计学意义 (P＜0.05);Logistic分析结果显示, 血清chemerin、omentin-1、APN、IL-1β、TNF-α水平是KD患儿急性期及CAL发生的独立影响因素 (P＜0.05)。结论:KD患儿存在较为严重的脂质代谢紊乱及炎症反应, 且急性期及CAL患儿的脂质代谢紊乱及炎症反应更严重, 提示chemerin、omentin-1、APN、IL-1β、TNF-α可作为评估KD发生发展的重要指标。Abstract: Objective: To discuss the detection and significance of serum adipose factor chemerin, omentin-1, adiponectin (APN), interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) in children with Kawasaki disease (KD).Method: Ninty-eight children with KD were selected as KD group from June 2015 to June 2018 in our Hospital, 30 healthy children were selected as the health group from medical examination center at the same time, the serum chemerin, omentin-1, APN, IL-1 beta and TNF-alpha levels were detected in all children's and their significance was analyzed.Result: The serum chemerin, IL-1 beta and TNF-alpha in the KD group were significantly higher than those in the healthy group, the serum omentin-1, APN in the KD group were significantly lower than those in the healthy group, the difference was statistically significant (P＜0.05).In KD group, the serum chemerin, IL-1 beta and TNF-alpha in the acute phase children were significantly higher than those in the subacute stage children, the serum omentin-1, APN in the acute phase children were significantly lower than those in the subacute stage children, the serum chemerin, IL-1 beta and TNF-alpha in the CAL children were significantly higher than those in the non CAL children, the serum omentin-1, APN in the CAL children were significantly lower than those in the non CAL children, the difference was statistically significant (P＜0.05).Logistic analysis showed that, serum chemerin, omentin-1, APN, IL-1 beta and TNF-alpha levels were the independent factors of the occurrence of acute phase and CAL in children with KD (P＜0.05).Conclusion: Children with KD have serious disorder of lipid metabolism and inflammatory response, and the disorder of lipid metabolism and inflammatory response are more serious in acute phase and CAL children, it is suggested that chemerin, omentin-1, APN, IL-1 beta, and TNF-alpha can be used as the important index to evaluate the development of KD.
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Key words:
- Kawasaki disease /
- adipose factor chemerin /
- omentin-1 /
- adiponectin /
- interleukin 1 beta /
- tumor necrosis factor alpha
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