CHINET surveillance of carbapenem-resistant gram-negative bacteria in China from 2005 to 2017
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摘要: 目的:从中国CHINET多年监测结果分析常见革兰阴性菌对碳青霉烯类抗生素耐药情况, 为临床使用碳青霉烯类药物提供流行病学依据。方法:登陆http://www.chinets.com, 收集2005-2017年中国CHINET细菌耐药性监测数据结果, 对常见细菌数量进行构成比的趋势分析。结果:临床标本分离菌中革兰阴性菌 (65.7%~72.6%) 已经明显超过革兰阳性菌 (27.0%~34.3%), 其中革兰阴性菌主要为肠杆菌科细菌和不发酵糖细菌, 革兰阳性菌主要为葡萄球菌属细菌和肠球菌属细菌。除铜绿假单胞菌外, 革兰阴性菌对美罗培南和亚胺培南耐药率呈逐年增加。肠杆菌属细菌与不发酵糖细菌对碳青霉烯类药物耐药率比较, 后者明显高于前者, 其中鲍曼不动杆菌耐药率及增长率均居于首位, 铜绿假单胞菌耐药率次之。结论:中国常见革兰阴性菌对碳青霉烯类抗生素耐药已经明显突出, 尤其是鲍曼不动杆菌全国耐药率已经呈现爆发流行。Abstract: Objective: To analyze the surveillance of carbapenem-resistant gram-negative bacteria from the data of China CHINET and provide an epidemiological basis for clinical use of carbapenems.Method: We visited the website of http://www.chinets.com and collected the monitoring data of China CHINET from 2005 to 2017.We analyzed the proportions of common bacteria.Result: Gram-negative bacteria (65.7%-72.6%, mainly including Enterobacteriaceae and Non-fermentative bacteria) significantly exceeded gram-positive bacteria (27.0%-34.3%, mainly including Staphylococcus and Enterococcus) in the isolated bacteria of clinical specimens.Except Pseudomonas aeruginosa, the resistance rate to meropenem and imipenem have increased year by year in gram-negative bacteria.Compared with Non-fermentable bacteria, Enterobacteriaceae have higher carbapenem-resistant rate, and the resistant and growth rate of Acinetobacter baumannii taken the first place, which was followed by Pseudomonas aeruginosa.Conclusion: The carbapenem-resistant gram-negative bacteria has been obviously prominent in China, especially Acinetobacter baumannii has been in a nationwide outbreak.
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Key words:
- gram-negative bacteria /
- carbapenem /
- antibiotic resistance
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