血清肾上腺髓质素前体在急性中毒患者中的应用分析

周峰; 刘志祯; 蔡华忠; 张浩

doi:10.13201/j.issn.1009-5918.2018.09.012

血清肾上腺髓质素前体在急性中毒患者中的应用分析

- 江苏大学附属医院急诊科(江苏镇江, 212001)

详细信息

通讯作者: 刘志祯,E-mail:zhouf404891231@126.com

中图分类号: R595

收稿日期: 2018-05-22

Analysis of the application of serum precursor adrenomedullin in acute intoxication

- Department of Emergency, the Affliated Hospital of Jiangsu Univesity, Zhenjiang, Jiangsu, 212001, China

More Information

Corresponding author: LIU Zhizhen, E-mail: zhouf404891231@126.com

Received Date: 22 May 2018

摘要

摘要: 目的:探讨血清肾上腺髓质素前体(pro-ADM)对急性中毒患者病情评估的应用价值。方法:检测我院98例中毒患者(中毒组)和30例对照组的血清pro-ADM,并对中毒患者进行入院的APACHE Ⅱ评分。根据30 d预后情况将中毒组分为死亡组(18例)、存活组(80例),比较中毒组与对照组的血清pro-ADM,并比较死亡组与中毒组、对照组的血清pro-ADM及APACHE Ⅱ评分,将中毒患者血清pro-ADM及APACHE Ⅱ评分进行相关性分析。采用受试者工作曲线(ROC)进行血清pro-ADM及APACHE Ⅱ评分在中毒患者预后分析。结果:①死亡组患者的pro-ADM及APACHE Ⅱ评分明显高于存活组(P<0.01),血清pro-ADM与APACHE Ⅱ评分呈正相关(r=0.625,P<0.01);②pro-ADM的AUC为0.794,95%可信区间为0.687~0.902,APACHE Ⅱ评分AUC为0.725,95%可信区间0.598~0.852;③ROC曲线中,pro-ADM截断值为1.99,敏感度0.833,特异度0.725,APACHE Ⅱ评分截断值14.5,敏感度0.778,特异度0.487。结论:急性中毒患者血清pro-ADM水平升高,联合检测pro-ADM和APACHE Ⅱ评分对急性中毒患者预后有一定的应用价值。
- 肾上腺髓质素前体 /
- 中毒 /
- 预后
Abstract: Objective:To explore the application value of serum precursor adrenomedullin(pro-ADM)in the assessment of patients with acute poisoning. Method:The serum pro-ADM of 98 cases of intoxication patients and 30 control groups in our hospital were measured and the APACHE Ⅱ score of the intoxication patients was evaluated.The serum pro-ADM levels of the poisoning group and the control group were compared.The serum pro-ADM and APACHE Ⅱ scores of the death group,the poisoning group and the control group were compared.The correlation between serum pro-ADM and APACHE Ⅱ scores of the poisoning patients was analyzed.The outcome of serum pro-ADM and APACHE Ⅱ scores in patients with poisoning was analyzed with the subjects' working curve(ROC). Result:①The scores of pro-ADM and APACHE Ⅱ in the death group were significantly higher than those in the survival group(P<0.01),Positive correlation was found between serum pro-ADM and APACHE Ⅱ score(r=0.625,P<0.01);②Under the ROC curve,the AUC of pro-ADM is 0.794,the 95% confidence interval is 0.687-0.902,the APACHE Ⅱ score AUC is 0.725,and the 95% confidence interval 0.598-0.852;③In the ROC curve,the truncated value of pro-ADM was 1.99,the sensitivity was 0.833,the specificity was 0.725,the truncated value of APACHE Ⅱ score was 14.5,the sensitivity was 0.778,and the specificity was 0.487.Conclusion:The level of serum pro-ADM in patients with acute poisoning is higher.The combined detection of pro-ADM and APACHE Ⅱ score has a certain value in the prognosis of patients with acute poisoning.
- precursor adrenomedullin /
- poisoning /
- prognosis

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