The relationship between the distribution of red blood cells and the degree of coronary atherosclerosis in patients with coronary heart disease
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摘要: 目的:研究红细胞分布宽度与冠心病患者冠状动脉粥样硬化程度的关系。方法:选取江苏省人民医院行经皮冠状动脉介入治疗(PCI)的636例心绞痛患者(稳定型心绞痛122例,不稳定型心绞痛514例),男417例,女219例;平均年龄(63.68±9.85)岁,其中单支病变组322例,双支病变组174例,三支病变组140例。比较3组患者一般临床资料及RDW水平;采用Pearson法进行RDW水平与冠状动脉Gensini评分之间的相关分析。结果:随着冠脉病变支数的增加,RDW逐渐升高,差异具有统计学意义(P<0.05),双变量相关分析结果显示,RDW与Gensini积分存在正相关(r=0.133,P<0.01),线性相关性良好,RDW随着Gensini积分增加(冠状动脉病变程度严重性的升高)而升高。结论:RDW与冠心病心绞痛患者冠状动脉粥样硬化程度有关,冠状动脉粥样硬化越严重血清RDW越高,其生物学机制需要进一步研究。Abstract: Objective:To study the relationship between the distribution of red blood cells and the degree of coronary atherosclerosis in patients with coronary heart disease.Method:A total of 636 patients with coronary heart disease received percutaneous coronary intervention (PCI) in Jiangsu province people's hospital, including 122 cases of stable angina pectoris and 514 cases of unstable angina, were retrospectively studied, 417 cases of male and 219 cases of female, mean age (63.68±9.85) years old, Groups were divided by the number of branch lesion, 322 cases of single branch lesion, 174 cases of double branch lesion and 140 cases of three branch lesion.Clinical data and patients' RDW level among the three groups of patients were compared.The correlation analysis between RDW and Gensini scores of coronary artery was performed using Pearson method.Result:With the increase of the number of coronary lesions, RDW gradually increased, and the difference was statistically significant (P<0.05).The results showed that the correlation between RDW and Gensini score was positive, meanwhile, the liner correlation was good, and RDW increased with the increase of Gensini score (the severity of coronary artery disease).Conclusion:There is an interaction between RDW and the degree of coronary atherosclerosis in patients with coronary heart disease, and the serum RDW level increases with the severity of coronary atherosclerosis.Its biological mechanism needs further study.
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