早期应用硫酸镁对急性结石性胆囊炎患者的临床效果

谭金波; 李剑; 邓艳斌; 王齐兵

doi:10.13201/j.issn.1009-5918.2017.04.011

早期应用硫酸镁对急性结石性胆囊炎患者的临床效果

- 1. 恩施土家族苗族自治州中心医院西医部急诊外科(湖北恩施, 445600);
- 2. 恩施土家族苗族自治州中心医院西医部骨科

详细信息

通讯作者: 王齐兵, E-mail:3148517329@qq.com

中图分类号: R657.4

收稿日期: 2017-01-17

The effect of early application of magnesium sulfate on the clinical symptoms and the level of plasma VIP and MTL in patients with ACC

- 1 Department of Emergency Surgery, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445600, China;
- 2 Department of Orthopaedics, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture

More Information

Corresponding author: WANG Qibing, E-mail: 3148517329@qq.com

Received Date: 17 January 2017

摘要

摘要: 目的: 探讨早期使用硫酸镁治疗急性结石性胆囊炎(ACC)患者对临床症状、血浆血管活性肠肽(VIP)、胃动素(MTL)水平的影响。方法: 选取2014-01-2016-03在我院治疗的120例ACC患者,采用前瞻性随机研究方法分为硫酸镁组和常规组,每组各60例。2组患者入院后均采用标准的非手术治疗方法,硫酸镁组入院后即给予50 ml硫酸镁进行治疗,后每8 h给药1次,对比2组临床症状缓解情况、实施急诊手术治疗率等指标。结果: 治疗48 h内,硫酸镁组的上腹部疼痛、发热、恶心呕吐、压痛及Murphy征阳性缓解率分别为78.33%、70.59%、91.89%和78.33%,常规组分别为61.67%、68.09%、85.29%和61.67%,硫酸镁组的上腹部疼痛、压痛及Murphy征阳性缓解率均显著高于常规组(P<0.05);治疗48 h后,硫酸镁组患者的WBC、N%、CRP、TBIL和VIP水平低于常规组(P<0.05),MTL水平高于常规组(P<0.05);硫酸镁组非手术方案治愈率与常规组比较差异无统计学意义(11.67% vs.6.67%,P>0.05);硫酸镁组的急诊手术率低于常规组的(13.33% vs.30.00%,P<0.05);硫酸镁组择期手术率与常规组比较差异无统计学意义(75.00% vs.63.33%,P>0.05)。结论: 早期使用硫酸镁治疗ACC患者能显著缓解患者的临床症状及体征,改善炎症反应水平,降低急诊手术率。
- 硫酸镁 /
- 急性结石性胆囊炎 /
- 血管活性肠肽 /
- 胃动素
Abstract: Objective: To investigate the effect of magnesium sulfate on the clinical symptoms,the expressions of plasma vasoactive intestinal peptide (VIP) and motilin (MTL) in patients with acute calculous cholecystitis ACC). Method: One hundred and twenty patients with ACC treated in our hospital from January 2014 to March 2016were divided into the magnesium sulfate group and the conventional group at random.All patients were treated with the standard non-surgical therapy.The patients in the magnesium sulfate group were treated with magnesium sulfate 50 ml after admission and repeated every 8 hour.The clinical symptoms and the rate of the implementation of the emergency surgery were compared. Result: After 48 hours treatment,the symptoms remission rate of the upper abdominal pain,fever,nausea and vomiting,tenderness and Murphy sign were 78.33%,70.59%,91.89%,78.33% in the magnesium sulfate group and 61.67%,68.09%,85.29%,61.67% in the conventional group respectively.The symptoms remission rate of the upper abdominal pain,tenderness and positive Murphy sign were significantly higher than those in the conventional group (P<0.05).The WBC,N%,CRP,TBIL,VIP levels in the magnesium sulfate group were lower than those in the conventional group (P<0.05),and the level of MTL in the magnesium sulfate group was higher than that in the conventional group (P<0.05).The cure rate had no significant difference between the magnesium sulfate group and the conventional group(11.67% vs.6.67%,P>0.05).The emergency operation rate of the magnesium sulfate group was lower than that of the conventional group (P<0.05).There was no significant difference in the rate of elective surgery between the magnesium sulfate group and the conventional group (P>0.05). Conclusion: Early application of magnesium sulfate can significantly relieve the clinical symptoms and signs of patients with ACC,reduce the level of inflammatory response and the rate of emer-gency surgery.
- magnesium sulfate /
- acute cholecystitis /
- vasoactive intestinal peptide /
- motilin

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