Clinical analysis of serum electrolyte disturbance in the poisoning patients treated with gastric lavage
-
摘要: 目的: 探讨口服中毒患者洗胃治疗后血清电解质异常发病的相关因素。方法: 回顾分析我院2015-06-2016-12收治的给予清水洗胃的147例中毒患者临床资料。结果: 洗胃后血清电解质异常的发病率为71.43%,其中钾离子37.41%、钠离子26.53%、氯离子23.81%、钙离子27.89%。147例中毒患者的28 d病死率为42.18%,死亡组和存活组患者白细胞计数、中性粒细胞计数、血红蛋白、血清钾离子浓度、尿素氮、肌酐比较差异有统计学意义(P<0.05),其中死亡组中重度低钾血症的发病率(29.03%)大于存活组(4.71%)。洗胃液量(GV)<20 L组血清钾离子浓度大于GV≥20 L组(P<0.05)。结论: 中毒患者洗胃后较易发生血清电解质的异常,以血清钾离子最为多见,尤其在GV≥20 L时。Abstract: Objective: To investigate the related factors of serum electrolyte derangement after gastric lavage (GL) in oral poisoning patients. Method: The clinical data of 147 patients treated with GL in our hospital were analyzed retrospectively. Result: The incidence of serum electrolyte derangement was 71.43% after GL,including 37.41% potassium ion,26.53% sodium ion,23.81% chloride ion and 27.89% calcium ion.Total 28 d mortality rate was 42.18%.The white blood cell count,neutrophil count,hemoglobin,serum potassium concentration,blood urea nitrogen and serum creatinine in death group and survival group were significantly different (P<0.05,respectively).The incidence of moderate to severe hypokalemia (K<3.0 mmol/L) in death group (29.03%) was higher than that in survival group (4.71%).The serum potassium concentration in the GV<20 L group was higher than that in the GV ≥ 20 L group (P<0.05). Conclusion: The serum electrolytes derangement are more likely to occur after GL in patients with poisoning,and lectrolyte disorders are more common in serum potassium,especially when GV ≥ 20 L.
-
Key words:
- poisoning /
- gastric lavage /
- electrolyte /
- hypokalemia
-
-
[1] 陆一鸣, 盛慧球.我国急性中毒的现状分析及其专业发展特点[J].中华急诊医学杂志, 2010, 19 (4):341-344.
[2] Mowry J B, Spyker D A, Brooks D E, et al.2015 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS):33rd Annual Report[J].Clin Toxicol (Phila), 2016, 54 (10):924-1109.
[3] 黎敏, 李超乾, 卢中秋, 等.急性中毒诊断与治疗中国专家共识[J].中华急诊医学杂志, 2016, 25 (11):1361-1376.
[4] 吕世进, 赖登攀, 严倩.急诊洗胃后电解质紊乱的临床研究[J].中国现代医生, 2016, 54 (10):91-96.
[5] Vale J A.Position statement:gastric lavage.American Academy of Clinical Toxicology;European Association of Poisons Centres and Clinical Toxicologists[J].J Toxicol Clin Toxicol, 1997, 35 (7):711-719.
[6] Benson B E, Hoppu K, Troutman W G, et al.Position paper update:gastric lavage for gastrointestinal decontamination[J].Clin Toxicol (Phila), 2013, 51 (3):140-146.
[7] Donkor J, Armenian P, Hartman I N, et al.Analysis of gastric lavage reported to a statewide poison control system[J].J Emerg Med, 2016, 51 (4):394-400.
[8] Westergaard B, Hoegberg L C, Groenlykke T B.Adherence to international recommendations for gastric lavage in medical drug poisonings in Denmark 2007-2010[J].Clin Toxicol (Phila), 2012, 50 (2):129-35.
[9] 黄培培, 马天龙, 张劲松.洗胃对猪百草枯灌胃模型的清除效果分析[J].中华急诊医学杂志, 2016, 25 (11):1381-1386.
[10] Tenenbein M, Cohen S, Sitar D S.Efficacy of ipecacinduced emesis, orogastric lavage, and activated charcoal for acute drug overdose[J].Ann Emerg Med, 1987, 16 (8):838-841.
-
计量
- 文章访问数: 18
- PDF下载数: 20
- 施引文献: 0