硝酸甘油对急性心肌梗死患者病死率影响的Meta分析

赵立志; 姜晓莉; 苟冬梅; 李东泽; 曾锐

doi:10.13201/j.issn.1009-5918.2017.04.001

硝酸甘油对急性心肌梗死患者病死率影响的Meta分析

- 1. 西南医科大学附属第二医院心脑病科(四川泸州, 646000);
- 2. 四川大学华西医院急诊科;
- 3. 四川大学华西医院心脏内科
基金项目:
四川省卫生和计划生育委员会科研项目 (No:16PJ305)

泸州-西南医大联合基金项目 (No:2016LZXNYD-J04)

详细信息

通讯作者: 曾锐, E-mail:zengrui_0524@126.com

中图分类号: R542.2

收稿日期: 2017-03-13

Effects of nitroglycerin on mortality in patients with acute myocardial infarction:A Meta analysis

- 1 Department of Cardiology, Second Affiliated Hospital of Southwest Medical University, Luzhou 646000, China;
- 2 Department of Emergency Medicine, West China Hospital, Sichuan University;
- 3 Department of Cardiology, West China Hospital, Sichuan University

More Information

Corresponding author: ZENG Rui, E-mail: zengrui_0524@126.com

Received Date: 13 March 2017

摘要

摘要: 目的: 通过Meta分析评价硝酸甘油对急性心肌梗死患者病死率的影响。方法: 计算机检索CBM、维普、万方、中国知网及PubMed数据库,检索时间截止至2017年2月,收集关于硝酸甘油治疗急性心肌梗死的随机对照研究,由2名评价者按照纳入和排除标准独立选择文献、提取资料、评价质量,交叉核对并进行方法学质量评估,采用Stata11.0统计软件进行Meta分析。结果: 最终纳入11篇文献,包括1421例患者,其中硝酸甘油治疗组(实验组)715例,常规或安慰剂治疗组(对照组)706例。异质性分析结果提示该研究具有较好的同质性(P=0.117),采用固定效应模型进行Meta分析。结果显示,硝酸甘油可以降低急性心肌梗死患者的病死率(OR=0.65,95%CI:0.47~0.90,P=0.01),同时敏感性分析提示敏感性低。结论: 硝酸甘油可以降低急性心肌梗死患者的病死率。
- 硝酸甘油 /
- 急性心肌梗死 /
- 病死率 /
- Meta分析
Abstract: Objective: To access the effect of nitroglycerin on mortality in patients with acute myocardial infarction (AMI) via Meta analysis. Method: The randomized controlled trials regarding nitroglycerin on AMI were searched from CBM,VIP,WANFANG data,CNKI and PubMed until Feb.2017.According to inclusion and exclusion criteria,2 reviewers independently choose and extracte data,cross-check and assess in the quality and methodology.All data were given meta analysis by using stata11.0 software. Result: A total of 11 articles and 1421 patients comprising 715 patients with nitroglycerin therapy (research group) and 706 patients with conventional therapy or placebo treatment (control group) were finally included.The included studies showed nitroglycerin can reduce mortality in patients with AMI (OR=0.65,95%CI:0.47~0.90,P=0.01),and the differences were statistically significant.No statistically significant heterogeneity was found in our analysis according to which we performed fixed effect model.And the sensitivity analysis showed that our results were reliable. Conclusion: Nitroglycerin can reduce mortality in patients with AMI.
- nitroglycerin /
- acute myocardial infarction /
- mortality /
- Meta analysis

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