NT-proBNP在低血容量性休克早期液体复苏中的意义

赵武民; 胡蛟龙; 卢伟智; 古勋清; 李晓红; 王玲玲

doi:10.13201/j.issn.1009-5918.2014.12.011

NT-proBNP在低血容量性休克早期液体复苏中的意义

- 佛山市第二人民医院急诊科(广东佛山, 528000)
基金项目:
2012年佛山市科技局医学类科技攻关项目 (No:201208072)

详细信息

通讯作者: 赵武民,E-mail:zwm0757@sina.com

中图分类号: R459.7

收稿日期: 2014-05-29

Significance of NT-proBNP’s in early fluid resuscitation of hemorrhagic shock

- Department of Emergency, Foshan Second Hospital, Foshan 528000, China

More Information

Corresponding author: ZHAO Wumin, E-mail: zwm0757@sina.com

Received Date: 29 May 2014

摘要

摘要: 目的:通过对心、肾功能正常的失血性休克患者早期液体复苏过程中N末端B型钠尿肽原(NT-proBNP)检测,探讨NT-proBNP在休克早期液体复苏中的意义。方法:快速NT-proBNP测定:采用罗氏心梗心衰检测仪cobas h 232 Cardiac System分析仪,观测39例休克患者来院后血清中NT-proBNP浓度在补液开始0、2、4、6 h的动态变化及其与血压变化的关系。结果:液体复苏后的6 h内,随着血压的恢复,NT-proBNP逐渐升高;从开始时的正常值范围(147.33±21.69) μg/L升高到6 h后的(402.18±20.37) μg/L。结论:失血性休克初期血清中NT-proBNP浓度升高并与血压恢复成正相关。
- NT-proBNP /
- 休克 /
- 液体复苏
Abstract: Objective:This study was designed to detect the concentration of NT-proBNP and to investigate the significance of NT-proBNP(N-terminal pro-brain natriuretic peptide)during early fluid resuscitation of the patients with hemorrhage shock but without kidney and cardiac dysfunction.Method:The relationship between dynamic changes of NT-proBNP and blood pressure in 39 patients with cobas h 232 Cardiac System analysis instrument was analyzed.At the point of 0,2,4,6 hour after fluid resuscitation,the NT-proBNP was measured through rapid determination.Result:In the early 6 hours of fluid resuscitation,NT-proBNP raised gradually with the recovery of blood pressure.It's concentration raised from a normal level (147.33±21.69) μg/L to (402.18±20.37) μg/L within 6 hours.Conclusion: NT-proBNP raised and had a positive correlation with the recovery of blood pressure during early period of shock in patients without kidney and cardiac dysfunction.
- NT-proBNP /
- Shock /
- fluid resuscitation

HTML全文

参考文献(7)

[1]	BOOTH J, PINNEY J, DAVENPORT A.N-terminalproBNP-marker of cardiac dysfunction, fluid overload, or malnutrition in hemodialysis patients[J].Clin J AmSoc Nephrol, 2010, 5:1036-1040.
[2]	王月妹.血清N端脑钠肽水平对血液透析患者容量负荷评估的价值[J].安徽医药, 2013, 17 (7):1191-1193.
[3]	SUBEQ Y M, HSU B G, LIN N T, et al.Hypothermiacaused by slow and limited-volume fluid resuscitationdecreases organ damage by hemorrhagic shock[J].Cytokine, 2012, 60:68-75.
[4]	HOYT D B.Fluid resuscitation:the target from an analysis of trauma systems and patient survival[J].TheJournal of trauma, 2003, 54:S31-35.
[5]	FRIESE R S, DINEEN S, JENNINGS A, et al.Serum Btype natriuretic peptide:a marker of fluid resuscitationafter injury[J].J Trauma, 2007, 62:1346-1350;discussion 1350-1351.
[6]	NT-proBNP临床应用中国专家共识小组.NT-proBNP临床应用中国专家共识[J].中国心血管病研究, 2011, 9 (6):401-408.
[7]	KIA M, COOLEY A, RIMMER G, et al.The efficacy ofB-type natriuretic peptide for early identification ofblood loss in traumatic injury[J].Am J Surg, 2006, 191:353-357.