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摘要: 目的：了解新生儿败血症血小板计数（BPC）和平均体积（MPV）的变化，分析其临床意义。方法：收集52例符合新生儿败血症确诊标准的患儿临床资料，比较败血症发生前后BPC及MPV相关变化；根据病原菌分为革兰阴性菌（G-）组和革兰阳性菌（G+）组，根据转归分为存活组和死亡组，进行上述相关参数分析。结果：败血症患儿血小板减少发生率53.8%；发病后与发病前相比，BPC显著降低，MPV增加（P<0.05）。G-组与G+组相比，血小板减少发生率显著升高（63.89%：31.25%）；BPC平均水平明显降低[（109.83±71.02）×109/L：（164.5±85.23）×109/L]，且最低点水平显著降低[（75.31±42.87）×109/L：（112.06±58.18）×109/L]。死亡组BPC和MPV较存活组降低[（59.91±28.83）×109/L：（144.49±78.80）×109/L]、[（9.61±0.98）：（11.22±1.27） fl]。结论：血小板减少和MPV增加与新生儿败血症相关，能较好地反映病情及预后。Abstract: Objective: To evaluate the kinetics of blood platelet count (BPC) and mean platelet volume (MPV) in neonatal sepsis and to analyze their clinical significance.Method: This study included 52 cases with neonatal sepsis.The parameters examined in each infant included platelet count,platelet nadir,incidence of thrombocytopenia,duration of thrombocytopenia,and MPV before and after onset.And enrolled infants were divided into Gram-negative bacteria (G-) group and Gram-positive bacteria (G+) group,survival group and dead group according to the classification of strains and turnover,respectively.Result: The sepsis episodes were correlated with thrombocytopenia,and increase in MPV.The platelet count and platelet nadir were statistically significantly lower in G- group than in G+ group[(109.83±71.02)×109/L:(164.5±85.23)×109/L],[(75.31±42.87)×109/L:(112.06±58.18)×109/L].And comparing with survival group,the platelet counts and MPV in death group were statistically lower[(144.49±78.80)×109/L:(59.91±28.83)×109/L],[(11.22±1.27) fl:(9.61±0.98) fl].Conclusion: Thrombocytopenia and increased MPV have strong correlation with neonatal sepsis,and can reflect the severity and prognosis of sepsis.
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Key words:
- neonatal sepsis /
- thrombocytopenia /
- platelet count /
- MPV
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