-
Abstract: Paraquat is one of the most widely used herbicide.Its toxicity is medium to animal but highly to human.The estimated lethal dose for adult is about 40mg/kg.The mechanism of paraquat poisoning is complicated and unclear.And there is no specific antidote.Current treatment is mainly focused on the comprehensive treatment, and the mortality rate is high.There is no breakthrough research progress on the paraquat poisoning.Recent studies on the therapy of paraquat poisoning are reviewed in this paper.
-
-
[1] HUANG M, ZHANG P, CHANG X L, et al.Change of oxidative stress and nuclear factor-kappa B in acute paraquat poisoned rats[J].Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2009, 27 (8) :457-462.
[2] HSU C W, LIN J L, LIN-TAN D T, et al.Early he-moperfusion may improve survival of severely pa-raquat-poisoned patients[J].PLoS One, 2012, 7:48397-48397.
[3] 邓朝霞, 熊建琼, 王涛, 等.血液灌流对百草枯中毒患者血浆浓度及预后的影响[J].中国急救医学, 2005, 25 (12) :928-929.
[4] ZHI Q, SUN H, QIAN X, et al.Edaravone, a novel an-tidote against lung injury and pulmonary fibrosis in-duced by paraquat[J]?Int Immunopharmacol, 2011, 11:96-102.
[5] ZERIN T, KIM Y S, HONG S Y, et al.Quercetin re-duces oxidative damage induced by paraquat via modu-lating expression of antioxidant genes in A549cells[J].J Appl Toxicol, 2012, 20:1002-1002.
[6] HARRISON F E, BEST J L, MEREDITH M E, et al.Increased expression of SVCT2in a new mouse model raises ascorbic acid in tissues and protects against pa-raquat-induced oxidative damage in lung[J].PLoS One, 2012, 7:35623-35623.
[7] LI L R, SYDENHAM E, CHAUDHARY B, et al.Glucocorticoid with cyclophosphamide for paraquat-induced lung fibrosis[J].Cochrane Database Syst Rev, 2012, 7:CD008084.
[8] AFZALIS S, GHOLYAF M.The effectiveness of combined treatment with methylpreDnisolone and cy-clophosphamide in oral paraquat poisoning[J].Arch I-ran Med, 2008, 11:387-931.
[9] GHAFFARI A R, NOSHAD H, ASTADI A, et al.Effect of pulse therapy with glucocorticoid and cyclo-phosphamide in lung fibrosis due to paraquat poison-ing in rats[J].Saudi Med J, 2011, 32:249-253.
[10] DI M, LI L, LAN C, et al.Effects of ulinastatin on my-ocardial injury induced by acute paraquat poisoning[J].Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, 2012, 24:342-345.
[11] ZHOU C Y, ZHANG Z J, LUO Y J, et al.Effect of ul-ilnastatin on the expression of heat shock protein70and NF-kappaB in lung tissue in rats with paraquat poisoned[J].Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2011, 29:280-283.
[12] ZHOU C Y, XIE S, LUO Y J, et al.Expression of the4-hydroxynonenal in lung tissue in rats with paraquat poisoned and the effect of ulinastatin[J].Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2012, 30:457-459.
[13] DJUKIC M M, JOVANOVIC M D, NINKOVIC M, etal.Protective role of glutathione reductase in paraquat induced neurotoxicity[J].Chem Biol Interact, 2012, 199:74-86.
[14] LI H, WU S, WANG Z, et al.Neuroprotective effects of tert-butylhydroquinone on paraquat-induced dopam-inergic cell degeneration in C57BL/6mice and in PC12cells[J].Arch Toxicol, 2012, 86:1729-1740.
[15] HE X, WANG L, SZKLARZ G, ET al.Resveratrol in-hibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid2-related factor2pathway[J].J Pharmacol Exp Ther, 2012, 342:81-90.
[16] SEIFIRAD S, KESHAVARZ A, TASLIMI S, et al.Effect of pirfenidone on pulmonary fibrosis due to pa-raquat poisoning in rats[J].Clin Toxicol (Phila) , 2012, 50:754-758.
[17] GHAZI-KHANSARI M, MOHAMMADI-KARAKA-NI A, SOTOUDEH M, et al.Antifibrotic effect of captopril and enalapril on paraquat-induced lung fibro-sis in rats[J].J Appl Toxicol, 2007, 27:342-349.
[18] 刘明伟, 林昕, 张明谦, 等.血必净对急性百草枯中毒鼠肺NF-кB活性及肺损伤保护的影响[J].重庆医学, 2010, 39 (1) :37-39.
[19] 任延波, 杨薇.姜黄素对百草枯致肺纤维化的临床研究[J].临床急诊杂志, 2012, 13 (2) :97-100.
[20] WRIGHT A F, GREEN T P, SMITH L L.The devel-opment of mouse monoclonal antibodies that bind and neutralize paraquat[J].Dev Biol stand, 66:495-501.
[21] CHEN N, BOWLES M R, POND S M.Prevention of paraquat toxicity in suspensions of alveolar type II cells by paraquat-specific antibodies[J].Hum Exp Toxicol, 1994, 13:551-557.
[22] 许崇恩, 郭玲, 张涛, 等.体外膜肺氧合技术抢救百草枯中毒的经验和教训[J].中国体外循环杂志, 2012, 10 (3) :148-150.
[23] WALDER B, BRUNDLER M A, SPILIOPOULOS A, et al.Successful single lung transplantation after pa-raqua.tintoxication[J].Transplation, 1997, 4:789-791.
-
计量
- 文章访问数: 321
- PDF下载数: 124
- 施引文献: 0