Abstract: Objective: To study the effects of different fluids on EGDT standards, blood lactate clearance, APACHEⅡscore and 28 d mortality in patients with septic shock after early fluid resuscitation.Method: From October 2005 to October 2010, patients with septic shock in ICU were enrolled and randomly divided into four groups according to the fluids used in resuscitation:hypertonic sodium chloride hydroxylethyl starch 40 group (Home group), 3% hypertonic saline solution group (HS group), Hydroxyethyl Starch 130/0.4 and Sodium Chloride (Wanwen group), normal salinegroup (NS group). Patients of different groups received fluid resuscitation via central vein, match with Ringers to treatment undergoing 6 h early goal directed therapy (EGDT). On the initial and after EGDT 1 h, 3 h, 6 h, hemodynamic parameters such as heart rate (HR), mean arterial blood pressure (MAP), and central venous pressure (CVP), 24 h blood concentration of lactate, and 24 h blood lactate clearance rate were detected. Attainment of EGDT, dosage of hypertensor, acute physiology and chronic health evaluation Ⅱ(APACHE II) scores before and 72 h after resuscitation, and 28 d mortality in patients were monitored.Result: 51 cases according to criteria were referred to our study, namely, Home group (n=12), HS group (n=10), Wanwen group (n=14), NS group (n=15). There were no differences in age, gender, MAP, CVP, HR, APACHEⅡ scoring value after admission to ICU and the initial blood concentration of lactate (P>0.05). There were significant differences of the study fluid volume in the four groups, NS grouP>Wanwen grouP>Home group (HS group) (P<0.05). And there were no difference of the total fluid volume between Home group and HS group, but significant differences in the three groups, NS grouP>Wanwen grouP>Home group (P<0.05). Along with the resuscitation, MAP and CVP increased, and HR decreased, but there were no difference of MAP and HR in the four groups. The CVP in Home group was significantly higher than in NS group 1 h, 3 h and 6 h after the fluid resuscitation (P<0.05, respectively), and also in Home group than Wanwen group (P<0.01), HS group than NS group 1 h after resuscitation (P<0.05), Home group than NS group at 6 h after resuscitation (P<0.05). There were no differences of 24 h blood concentration of lactate and clearance rate in the four groups, also no differences of other parameters such as APACHEⅡ scores 72 h after resuscitation, the number of patients requiring using hypertensor and that of using hypertensor>3 d, and the number of attainment of EGDT (P>0.05, respectively). 23 patients died (the overall mortality was 45.10%), and 28 d mortality showed no significant differences among these groups (P>0.05, respectively).Conclusion: In patients with septic shock receiving early fluid resuscitation, different kinds of fluid can achieve treatment goals, do not effect time of requiring using hypertensor, blood lactate clearance rate, APACHE Ⅱscore, and 28 d mortality. Compared with other fluids, hypertonic sodium chloride hydroxylethyl starch 40 or 3% hypertonic saline solution are a good alternative for lower total resuscitation volume to achieve the same goal.