气体信号分子硫化氢在新鲜骨折患者血浆中的变化

李瑞明; 刘志伟; 王聪; 刘文莉; 王海英; 涂家红; 赵斌

doi:10.13201/j.issn.1009-5918.2012.06.011

气体信号分子硫化氢在新鲜骨折患者血浆中的变化

- 北京积水潭医院急诊科(北京, 100035)

详细信息

通讯作者: 赵斌,E-mail:zhaobin60@yahoo.com.cn

中图分类号: R683

收稿日期: 2012-04-09

The changes of plasma hydrogen sulfide level in patients with fracture

- Department of Emergency, Beijing Jishuitan hospital, Beijin 100035, China

More Information

Corresponding author: ZHAO Bin, E-mail: zhaobin60@yahoo.com.cn

Received Date: 09 April 2012

摘要

摘要: 目的: 观察新鲜骨折患者血浆中内源性气体信号分子硫化氢水平的变化探讨其可能的临床意义。方法: 检测骨折患者血浆白细胞计数、中性粒细胞分类计数、血小板计数、纤维蛋白原、碱性磷酸酶含量和血浆硫化氢水平并与正常对照组进行对比分析。结果: 与对照组相比,血浆白细胞计数、中性粒细胞分类计数、血小板计数、纤维蛋白原和碱性磷酸酶含量在骨折时明显升高,而血浆硫化氢水平明显降低。结论: 新鲜骨折患者血浆硫化氢含量下降,其可能参与了骨折的病理过程。
- 骨折 /
- 硫化氢 /
- 血浆
Abstract: Objective: To investigated the plasma hydrogen sulfide (H₂S) level in patients with fracture and approach the effective of endogenous H₂S in the pathogenesis of fracture healing.Method: Peripheral white blood cells (WBC), the percentage of polymorphonuclear cells (PMN%), and platelets (PLT) were counted. Fibrinogen (FIB), alkaline phosphatase (ALP) and H₂S level in plasma were measured.Result: Compared with control group,white blood cells, the percentage of polymorphonuclear cells, and platelets were increased. Fibrinogen and alkaline phosphatase level in plasma were increased. While the H₂S level in plasma was decreased.Conclusion: The H₂S level in plasma was decreased in fracture patients, endogenous H₂S may involve inthe pathogenesis of fracture healing.
- fracture /
- endogenous hydrogen sulfide /
- plasma

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