革兰氏阳性球菌和革兰氏阴性杆菌导致医院感染的患者细胞免疫功能观察

龙盼; 姜丽静; 李响; 孙英杰; 张璐; 周若雯

doi:10.13201/j.issn.1009-5918.2015.12.019

革兰氏阳性球菌和革兰氏阴性杆菌导致医院感染的患者细胞免疫功能观察

- 复旦大学附属闵行医院(闵行区中心医院)重症监护病房(上海, 201199)

详细信息

通讯作者: 李响,E-mail:18918169826@163.com

中图分类号: R446.5

收稿日期: 2015-07-31

The influence of gram-positive cocci and gram-negative bacillus on the immune system

- ICU, Minhang Hospital, Fudan University, Shanghai 201199, China

More Information

Corresponding author: LI Xiang, E-mail: 18918169826@163.com

Received Date: 31 July 2015

摘要

摘要: 目的：观察不同类别淋巴细胞百分比对革兰氏阳性球菌和革兰氏阴性杆菌导致的医院感染患者的诊断价值。方法：选择我院重症监护病房确诊医院感染的患者67例。其中革兰氏阳性球菌引起的医院感染26例，革兰氏阴性杆菌引起的医院感染41例。比较2组患者性别、年龄、APACHEⅡ评分、T淋巴细胞、B淋巴细胞及CD4⁺、CD8⁺、NK细胞百分比及CD4⁺/CD8⁺比值。结果：2组患者年龄、性别、APACHEⅡ评分比较差异无统计学意义，患者白细胞计数、中性粒细胞百分比、降钙素原、C反应蛋白比较差异无统计学意义。淋巴细胞百分比中，T淋巴细胞、CD4⁺淋巴细胞、CD8⁺淋巴细胞、NK细胞、CD4⁺/CD8⁺比值比较差异无统计学意义（P>0.05）；B淋巴细胞百分比差异有统计学意义（P=0.03）。绘制受试者曲线（ROC），曲线下面积（AUC）为0.769，具有较大诊断价值。当B淋巴细胞百分比达到20.13%时，革兰氏阳性球菌感染的灵敏度为88.5%，特异度为68.3%。结论：革兰氏阳性球菌感染早期，B淋巴细胞百分比高于革兰氏阴性杆菌，B淋巴细胞百分比对判断革兰氏阳性球菌和革兰氏阴性杆菌导致的医院感染有诊断价值。
- 革兰氏阳性球菌 /
- 革兰氏阴性杆菌 /
- 医院感染 /
- B淋巴细胞
Abstract: Objective: To observe the diagnosis value of B lymphocyte to hospital infection from gram-positive cocci and gram-negative bacillus.Method: Sixty-seven patients with hospital infection were admitted,including 26 patients with gram-positive cocci and 41 patients with gram-negative bacillus.When hospital infection was diagnosed,ages,sexes,APACHEⅡ scores,T lymphocyte,B lymphocyte,CD4⁺,CD8⁺,NK cell,CD4⁺/CD8⁺ were compared.Result: There were no significant difference in ages,sexes,APACHEⅡ scores,T lymphocyte,CD4⁺,CD8⁺,NK cell,the ratio of CD4⁺/CD8⁺(P>0.05).There was difference in B lymphocyte(P=0.03).Drawing receiver operating characteristic (ROC),area under the curve (AUC) was 0.769,equipped with lager diagnosis value.When the percentage was more than 20.13%,the sensitivity to diagnose the infection of gram-positive cocci was 88.5%,specificity 68.3%.Conclusion: In the early infection of gram-positive cocci,the percentage of B lymphocyte is higher than that in gram-negative bacillus infection.The percentage of B lymphocyte was equipped with diagnosis value to differentiate the hospital infection from gram-positive cocci and gram-negative bacillus.
- gram-positive cocci /
- gram-negative bacillus /
- hospital infection /
- B lymphocyte

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