脓毒症患者行局部枸橼酸抗凝持续肾脏替代治疗过程中钙的管理

程晓红, 魏宁, 邵义明. 脓毒症患者行局部枸橼酸抗凝持续肾脏替代治疗过程中钙的管理[J]. 临床急诊杂志, 2021, 22(11): 779-784. doi: 10.13201/j.issn.1009-5918.2021.11.015
引用本文: 程晓红, 魏宁, 邵义明. 脓毒症患者行局部枸橼酸抗凝持续肾脏替代治疗过程中钙的管理[J]. 临床急诊杂志, 2021, 22(11): 779-784. doi: 10.13201/j.issn.1009-5918.2021.11.015
Calcium management during continuous renal replacement therapy with regional citrate anticoagulation in patients with sepsis[J]. J Clin Emerg, 2021, 22(11): 779-784. doi: 10.13201/j.issn.1009-5918.2021.11.015
Citation: Calcium management during continuous renal replacement therapy with regional citrate anticoagulation in patients with sepsis[J]. J Clin Emerg, 2021, 22(11): 779-784. doi: 10.13201/j.issn.1009-5918.2021.11.015

脓毒症患者行局部枸橼酸抗凝持续肾脏替代治疗过程中钙的管理

详细信息
    通讯作者: 邵义明,E-mail:Shaoyiming@163.com
  • 中图分类号: R459.7

Calcium management during continuous renal replacement therapy with regional citrate anticoagulation in patients with sepsis

More Information
  • 加载中
  • [1]

    Singer M,Deutschman CS,Seymour CW,et al.The Third International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3)[J].Jama,2016,315(8):801-810.

    [2]

    Liu C,Li M,Cao S,et al.Effects of HV-CRRT on PCT,TNF-alpha,IL-4,IL-6,IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure[J].Exp Ther Med,2017,14(4):3093-3097.

    [3]

    Bellomo R,Kellum JA,Ronco C,et al.Acute kidney injury in sepsis[J].Intensive Care Med,2017,43(6):816-828.

    [4]

    Yin F,Zhang F,Liu S,et al.The therapeutic effect of high-volume hemofiltration on sepsis:a systematic review and meta-analysis[J].Ann Transl Med,2020,8(7):488.

    [5]

    关姣,裴红红.行CRRT治疗的脓毒症患者的免疫状态变化探讨[J].临床急诊杂志,2019,20(8):649-652.

    [6]

    Stevens PE,Levin A.Evaluation and management of chronic kidney disease:synopsis of the kidney disease:improving global outcomes 2012 clinical practice guideline[J].Ann Intern Med,2013,158(11):825-830.

    [7]

    Fei M,Li P,Tao X,et al.Influence of hypocalcemia on the prognosis of septic patients[J].Zhonghua Wei Zhong Bing Ji Jiu Yi Xue,2019,31(4):418-421.

    [8]

    Rattis B A C,Freitas A C,Oliveira J F,et al.Effect of Verapamil,an L-Type Calcium Channel Inhibitor,on Caveolin-3 Expression in Septic Mouse Hearts[J].Oxid Med Cell Longev,2021,2021:6667074.

    [9]

    Veldurthy V,Wei R,Oz L,et al.Vitamin D,calcium homeostasis and aging[J].Bone Res,2016,4:16041.

    [10]

    Steele T,Kolamunnage-Dona R,Downey C,et al.Assessment and clinical course of hypocalcemia in critical illness[J].Crit Care,2013,17(3):R106.

    [11]

    Zhang Z,Xu X,Ni H,et al.Predictive value of ionized calcium in critically ill patients:an analysis of a large clinical database MIMIC Ⅱ[J].PLoS One,2014,9(4):e95204.

    [12]

    Liu Y,Chai Y,Rong Z,et al.Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis[J].Ann Nutr Metab,2020,76(3):193-200.

    [13]

    Zivin JR,Gooley T,Zager RA,et al.Hypocalcemia:a pervasive metabolic abnormality in the critically ill[J].Am J Kidney Dis,2001,37(4):689-698.

    [14]

    Collage R D,Howell G M,Zhang X,et al.Calcium supplementation during sepsis exacerbates organ failure and mortality via calcium/calmodulin-dependent protein kinase kinase signaling[J].Crit Care Med,2013,41(11):e352-360.

    [15]

    Qiu X,Dong K,Sun R.STIM1 Regulates Endothelial Calcium Overload and Cytokine Upregulation During Sepsis[J].J Surg Res,2021,263(4):236-244.

    [16]

    He W,Huang L,Luo H,et al.Hypocalcemia in sepsis:analysis of the subcellular distribution of Ca2+ in septic rats and LPS/TNF-alpha-treated HUVECs[J].J Infect Dev Ctries,2020,14(8):908-917.

    [17]

    Zhang W,Bai M,Yu Y,et al.Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients:a systematic review and meta-analysis[J].Crit Care,2019,23(1):22.

    [18]

    Mariano F,Hollo' Z,Depetris N,et al.Coupled-plasma filtration and adsorption for severe burn patients with septic shock and acute kidney injury treated with renal replacement therapy[J].Burns,2020,46(1):190-198.

    [19]

    Klingele M,Baerens L.Impact of Renal Replacement Therapy on Mortality in Critically Ill Patients-The Nephrologist's View within an Interdisciplinary Intensive Care Team[J].J Clin Med,2021,10(15):890-898.

    [20]

    Giani M,Scaravilli V,Stefanini F,et al.Continuous Renal Replacement Therapy in Venovenous Extracorporeal Membrane Oxygenation:A Retrospective Study on Regional Citrate Anticoagulation[J].ASAIO J,2020,66(3):332-338.

    [21]

    Arnold F,Westermann L,Rieg S,et al.Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19:a cohort study[J].BMC Nephrol,2020,21(1):486.

    [22]

    施建设,陈佳海,蓝亮光,等.血浆NGAL指导腹腔感染并发急性肾损伤选择CRRT时机的临床研究[J].临床急诊杂志,2020,21(3):212-217.

    [23]

    Sponholz C,Bayer O,Kabisch B,et al.Anticoagulation strategies in venovenous hemodialysis in critically ill patients:a five-year evaluation in a surgical intensive care unit[J].ScientificWorldJournal,2014,2014:808320.

    [24]

    Oudemans-Van Straaten H M,Ostermann M.Bench-to-bedside review:Citrate for continuous renal replacement therapy,from science to practice[J].Crit Care,2012,16(6):249.

    [25]

    Zheng Y,Xu Z,Zhu Q,et al.Citrate Pharmacokinetics in Critically Ill Patients with Acute Kidney Injury[J].PLoS One,2013,8(6):e65992.

    [26]

    Rhee H,Berenger B,Mehta RL,et al.Regional Citrate Anticoagulation for Continuous Kidney Replacement Therapy With Calcium-Containing Solutions:A Cohort Study[J].Am J Kidney Dis,2021,78(4):550-559.

    [27]

    Shum H P,Chan K C,Yan W W.Regional citrate anticoagulation in predilution continuous venovenous hemofiltration using prismocitrate 10/2 solution[J].Ther Apher Dial,2012,16(1):81-86.

    [28]

    Klingele M,Stadler T,Fliser D,et al.Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction[J].Crit Care,2017,21(1):294.

    [29]

    Jacobs R,Honore P M,Bagshaw S M,et al.Citrate Formulation Determines Filter Lifespan during Continuous Veno-Venous Hemofiltration:A Prospective Cohort Study[J].Blood Purif,2015,40(3):194-202.

    [30]

    Kirwan CJ,Hutchison R,Ghabina S,et al.Implementation of a Simplified Regional Citrate Anticoagulation Protocol for Post-Dilution Continuous Hemofiltration Using a Bicarbonate Buffered,Calcium Containing Replacement Solution[J].Blood Purif,2016,42(4):349-355.

    [31]

    Ong SC,Wille KM,Speer R,et al.A continuous veno-venous hemofiltration protocol with anticoagulant citrate dextrose formula A and a calcium-containing replacement fluid[J].Int J Artif Organs,2014,37(6):499-502.

    [32]

    Broman M,Klarin B,Sandin K,et al.Simplified Citrate Anticoagulation for CRRT Without Calcium Replacement[J].ASAIO J,2015,61(4):437-442.

    [33]

    Cointault O,Kamar N,Bories P,et al.Regional citrate anticoagulation in continuous venovenous haemodiafiltration using commercial solutions[J].Nephrol Dial Transplant,2004,19(1):171-178.

    [34]

    Gupta M,Wadhwa N K,Bukovsky R.Regional citrate anticoagulation for continuous venovenous hemodiafiltration using calcium-containing dialysate[J].Am J Kidney Dis,2004,43(1):67-73.

    [35]

    韩锦,王欣,李侠,等.枸橼酸盐两段式抗凝在含钙置换液连续性肾脏替代治疗中的抗凝效果[J].山西医科大学学报,2019,50(12):1750-1754.

    [36]

    Sheng RM,Zhao WB,Huang LH,et al.A target-oriented algorithm for maintaining serum calcium stability automatically in regional citrate anticoagulation[J].Int J Artif Organs,2021,44(8):551-559.

    [37]

    胡新,毛智,李青霖,等.新型含枸橼酸无钙置换液在重症患者血液净化治疗中的抗凝效果[J].解放军医学杂志,2020,45(12):1259-1264.

    [38]

    Zheng Y,Xu Z,Fan Q,et al.Calcium supplementation in CVVH using regional citrate anticoagulation[J].Hemodial Int,2019,23(1):33-41.

    [39]

    Järvisalo MJ,Hellman T,Uusalo P.Mortality and associated risk factors in patients with blood culture positive sepsis and acute kidney injury requiring continuous renal replacement therapy-A retrospective study[J].PLoS One,2021,16(4):e0249561.

    [40]

    Luo L,Fan M,Chen Q,et al.A simplified protocol for individualized regional citrate anticoagulation for hemodialysis:A single-center,randomized clinical study[J].Medicine(Baltimore),2021,100(8):e24639.

    [41]

    Tolwani A J,Prendergast M B,Speer R R,et al.A practical citrate anticoagulation continuous venovenous hemodiafiltration protocol for metabolic control and high solute clearance[J].Clin J Am Soc Nephrol,2006,1(1):79-87.

    [42]

    Schultheiss C,Saugel B,Phillip V,et al.Continuous venovenous hemodialysis with regional citrate anticoagulation in patients with liver failure:a prospective observational study[J].Crit Care,2012,16(4):R162.

    [43]

    Warnar C,Faber E,Katinakis P A,et al.Electrolyte monitoring during regional citrate anticoagulation in continuous renal replacement therapy[J].J Clin Monit Comput,2021.

    [44]

    Zhang Q,Zhuang F,Fan Q,et al.The possibility of using effluent ionized calcium to assess regional citrate anticoagulation in continuous renal replacement therapy[J].Int J Artif Organs,2020,43(6):379-384.

    [45]

    Evenepoel P,Maes B,Vanwalleghem J,et al.Regional citrate anticoagulation for hemodialysis using a conventional calcium-containing dialysate[J].Am J Kidney Dis,2002,39(2):315-323.

    [46]

    Boer W,van Tornout M,Solmi F,et al.Determinants of Total/ionized Calcium in patients undergoing citrate CVVH:A retrospective observational study[J].J Crit Care,2020,59:16-22.

    [47]

    Link A,Klingele M,Speer T,et al.Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients[J].Critical Care Medicine,2012,16(3):R97.

    [48]

    Fall P,Szerlip H M.Continuous renal replacement therapy:cause and treatment of electrolyte complications[J].Semin Dial,2010,23(6):581-585.

    [49]

    Tolwani A,Wille K M.Advances in continuous renal replacement therapy:citrate anticoagulation update[J].Blood Purif,2012,34(2):88-93.

    [50]

    Liu D L,Huang L F,Ma W L,et al.Determinants of Calcium Infusion Rate During Continuous Veno-venous Hemofiltration with Regional Citrate Anticoagulation in Critically Ill Patients with Acute Kidney Injury[J].Chin Med J(Engl),2016,129(14):1682-1687.

    [51]

    谢天驰.在CRRT治疗脓毒症急性肾损伤中应用局部枸橼酸抗凝与全身肝素化抗凝的疗效对比分析[J].中国现代药物应用,2020,14(22):171-173.

    [52]

    Bi X,Zhang Q,Zhuang F,et al.Optimized calcium supplementation approach in post-dilution CVVHDF using regional citrate anticoagulation[J].Int J Artif Organs,2021,44(3):165-173.

    [53]

    叶涛,余追.局部枸橼酸钠抗凝对连续性肾脏替代治疗患者补钙速率的影响[J].内科急危重症杂志,2016,22(2):125-126.

    [54]

    Wu S,Xu T,Wu C,et al.Continuous renal replacement therapy in sepsis-associated acute kidney injury:Effects on inflammatory mediators and coagulation function[J].Asian J Surg,2021,S1015-9584(21):00098-1.

  • 加载中
计量
  • 文章访问数:  210
  • PDF下载数:  276
  • 施引文献:  0
出版历程
收稿日期:  2021-09-01

目录