外周血miR-181a对慢性阻塞性肺疾病急性加重患者28d死亡的预测价值

王慧; 杨淼; 任慧敏; 韩树池; 薛乾隆; 韩宝华

doi:10.13201/j.issn.1009-5918.2021.11.010

外周血miR-181a对慢性阻塞性肺疾病急性加重患者28d死亡的预测价值

- 河北北方学院附属第一医院急诊科(河北张家口, 075000)
基金项目:
2019年度河北省医学科学研究课题计划(No:20190903)

详细信息

通讯作者: 王慧,E-mail:wangh011@163.com

中图分类号: R563.9

收稿日期: 2021-08-26

Predictive value of miR-181a in peripheral blood on 28 day death in patients with acute exacerbation of chronic obstructive pulmonary disease

- Department of Emergency, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, 075000, China

More Information

Corresponding author: WANG Hui, E-mail: wangh011@163.com

Received Date: 26 August 2021

摘要

摘要: 目的:研究外周血miR-181a对慢性阻塞性肺疾病急性加重患者(AECOPD)28 d死亡的预测价值。方法:选择2017年10月-2019年12月期间在我院住院治疗的AECOPD患者作为AECOPD组,同期在门诊就诊的稳定期COPD患者作为稳定期COPD组、体检的健康者作为对照组。检测外周血miR-181a的表达水平及血清肿瘤坏死因子-α(TNF-α)、IL-6、IL-8的含量。观察AECOPD患者的28 d死亡情况,采用ROC曲线分析miR-181a、TNF-α、IL-6、IL-8对28 d死亡的预测价值,采用Kaplan-Meier曲线分析miR-181a、TNF-α、IL-6、IL-8与28 d死亡的相关性,采用COX回归分析28 d死亡的影响因素。结果:AECOPD组患者外周血miR-181a的表达水平明显低于稳定期COPD组及对照组,血清TNF-α、IL-6、IL-8的含量明显高于稳定期COPD组及对照组(P<0.05)且miR-181a与TNF-α、IL-6、IL-8具有负相关关系;经ROC曲线分析,miR-181a、TNF-α、IL-6对AECOPD患者28 d死亡具有预测价值;经Kaplan-Meier曲线分析,AECOPD组中低miR-181a表达及高TNF-α、IL-6含量患者的28 d累积死亡率较高;经COX回归分析,miR-181a、TNF-α是AECOPD患者28 d死亡的影响因素。结论:AECOPD患者外周血miR-181a表达减少且与促炎因子释放及28 d累积死亡率增加有关,对28 d死亡具有预测价值。
- 慢性阻塞性肺疾病急性加重 /
- miR-181a /
- 促炎因子 /
- 预后 /
- 预测
Abstract: Objective:To study the predictive value of miR-181 a in peripheral blood on 28 day death in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:AECOPD patients hospitalized in our hospital from October 2017 to December 2019 were selected as AECOPD group, stable COPD patients in the outpatient department during the same period were selected as stable COPD group, and healthy people in physical examination were selected as control group. The expression of miR-181 a in peripheral blood and serum levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and interleukin-8(IL-8) were detected. The 28 day death of AECOPD patients was observed. ROC curve was used to analyze the predictive value of miR-181 a, TNF-α, IL-6, IL-8 on 28 d death. Kaplan Meier curve was used to analyze the correlation between miR-181 a, TNF-α, IL-6, IL-8 and 28 d death. COX regression was used to analyze the influencing factors of 28 d death.Results:The expression level of miR-181 a in peripheral blood of AECOPD group was significantly lower than that of stable COPD group and control group, serum TNF-α, IL-6, IL-8 levels were significantly higher than those of stable COPD group and control group(P<0.05), and miR-181 a was negatively correlated with TNF-α, IL-6 and IL-8; ROC curve analysis showed that, miR-181 a, TNF-α, IL-6 had predictive value for 28 day death of AECOPD patients; Kaplan Meier analysis curve showed that 28 d cumulative mortality of AECOPD patients with low miR-181 a expression and high TNF-α, IL-6 levels significantly increased; COX regression analysis showed that miR-181 a and TNF-α were the influencing factors of 28 day death of AECOPD patients.Conclusion:the expression of miR-181 a in peripheral blood of patients with AECOPD decreases, which relates to the increasing pro-inflammatory factors and t 28 day cumulative mortality, which also has predictive value for 28 day death.
- acute exacerbation of chronic obstructive pulmonary disease /
- miR-181a /
- proinflammatory factors /
- prognosis /
- prediction

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