同型半胱氨酸预测急性心肌梗死冠脉病变的研究

樊丹丹; 姚芳兰; 屈慧; 苗常青

doi:10.13201/j.issn.1009-5918.2021.04.008

同型半胱氨酸预测急性心肌梗死冠脉病变的研究

- 西安交通大学第一附属医院急诊科(西安, 710061)
基金项目:
国自然优秀青年科学基金项目(No:81822005)

详细信息

通讯作者: 苗常青,E-mail:mcqfree@163.com

中图分类号: R542.22

收稿日期: 2020-10-17

Homocysteine in predicting the severity of coronary artery in patients with acute myocardial infarction

- Department of Emergency, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China

More Information

Corresponding author: MIAO Changqing, E-mail: mcqfree@163.com

Received Date: 17 October 2020

摘要

摘要: 目的:探索血同型半胱氨酸浓度与急性心肌梗死(AMI)患者冠脉病变严重程度的关系。方法:选取符合纳入及排除标准的AMI患者共118例。根据冠脉病变支数分为单支病变组(n=17)、双支病变组(n=25)和三支病变组(n=76);同时将这118例患者进行冠脉Gensini评分,并依据四分位数分为组1(n=29),组2(n=31),组3(n=29),组4(n=29)。分别比较年龄、性别、既往吸烟史、饮酒史、高血压史、糖尿病史、家族冠心病史;入院24 h内血总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、超氧化物歧化酶、同型半胱氨酸、随机血糖、N端-B型前脑钠肽及入院72 h内左室射血分数。结果:性别、同型半胱氨酸、随机血糖为冠脉病变支数的危险因素(P<0.05);同型半胱氨酸及左室射血分数为Gensini评分的危险因素(P<0.05)。结论:血同型半胱氨酸水平是预测AMI患者冠脉病变严重程度的重要标记物。
- 急性心肌梗死 /
- 冠脉病变支数 /
- 冠脉Gensini评分 /
- 同型半胱氨酸
Abstract: Objective: To explore the relationship between homocysteine(Hcy)and the severity of coronary artery in patients with acute myocardial infarction(AMI).Methods: A total of 118 patients with acute myocardial infarction who met the inclusion and exclusion criteria of AMI were selected. Groups according to the numbers of coronary artery lesion: single vessel lesion group(n=17); double vessels lesion group(n=25); three vessels lesion group(n=76); Groups according to the quartile of Gensinis scores: group 1(n=29),group 2(n=31), group 3(n=29), group 4(n=29). Compare the differences of age, gender, history of hypertension, diabetes, smoking, drinking, and family history of coronary heart disease; the results of total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, superoxide dismutase, Hcy, random blood glucose, N-terminal B-type probrain natriuretic peptide within 24 hours after admission and left ventricular ejectin fraction within 72 hours.Results: Gender, Homocysteine and random blood glucose are risk factors for the numbers of coronary artery lesions(P<0.05); The Homocysteine, left ventricular ejection fraction are risk factors for Gensinis scores(P<0.05);Conclusion: Homocysteine is an important marker for the severity of coronary artery in patients with AMI.
- acute myocardial infarction /
- homocysteine /
- number of coronary artery lesions /
- Gensini scores

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