Presesin联合降钙素原对脓毒症患儿28d病死率预测价值研究

杨帆; 刘君; 王丹; 薛亚强; 岳远更; 刘佳

doi:10.13201/j.issn.1009-5918.2021.01.004

Presesin联合降钙素原对脓毒症患儿28d病死率预测价值研究

- 秦皇岛市妇幼保健院(河北秦皇岛, 066000)
基金项目:
秦皇岛市科技局基金项目(No:201805A064)

详细信息

通讯作者: 刘君,E-mail:szclj007@163.com

中图分类号: R737.9

收稿日期: 2020-07-01

Study on predictive value of presesin combined with PCT in 28-day mortality of children with sepsis

- Maternity and Child Care Center of Qinhuangdao, Qinhuangdao, Hebei, 066000, China

More Information

Corresponding author: LIU Jun, E-mail: szclj007@163.com

Received Date: 01 July 2020

摘要

摘要: 目的:探讨可溶性白细胞分化抗原14亚型(sCD14-ST,Presepsin)联合降钙素原(PCT)检测在脓毒症患儿28 d预后评价中的应用价值。方法:收集我院儿科收住的确诊为脓毒症的患儿132例。记录患儿一般情况,小儿危重病例评分(PCIS),采集静脉血并检测Presepsin、PCT及其他相关炎症指标的表达情况。随访28 d,根据患儿生存情况分为生存组和死亡组。多因素Logistic回归分析与脓毒症患儿28 d病死率相关的指标。采用Pearson相关分析检验Presepsin、PCT与PCIS的相关性。ROC曲线分析比较各指标对脓毒症患儿预后评估的价值。结果:随访28 d后,132例患儿中有48例死亡,病死率为35.82%。死亡组患儿血清Presepsin、PCT、CRP及WBC表达水平明显高于生存组,而PCIS评分明显低于生存组,差异具有统计学意义(P<0.05)。多因素Logistic回归分析表明,Presepsin、PCT及PCIS评分是脓毒症患儿死亡的独立危险因素(P<0.05)。Pearson相关性分析表明,Presepsin(r=-0.736,P<0.05)和PCT(r=-532,P<0.05)表达水平与PCIS评分呈负相关。ROC曲线分析结果显示Presepsin、PCT及PCIS评分曲线下面积(AUC)分别为0.851(95%CI:0.771~0.934)、0.806(95%CI:0.751~0.867)和0.748(95%CI:0.657~0.839)。Presepsin联合PCT检测的AUC值为0.942(95%CI:0.838~0.991)明显优于单一Presepsin和PCT检测AUC值(P<0.05)。结论:Presepsin联合PCT检测在预测脓毒症患儿病死率时具有重要的临床参考价值。
- Presesin /
- 降钙素原 /
- 脓毒症 /
- 病死率
Abstract: Objective: To explore the value of Presepsin combined with PCT in the evaluation of 28-day prognosis in children with sepsis.Methods: A total of 132 children with sepsis admitted to our hospital were collected.The general condition of the child, the pediatric critical case score(PCIS) was recorded.The expression of Presepsin, PCT and other related inflammatory markers was examined.After 28 days of follow-up, the survival and death groups were divided according to the survival of the children.Multivariate Logistic regression analysis was used to correlate with 28-day mortality in children with sepsis.Pearson correlation analysis was used to test the correlation between Presepsin, PCT and PCIS.ROC curve analysis compares the value of each index in evaluating the prognosis of children with sepsis.Results: After 28 days of follow-up, 48 of 132 patients died and the mortality rate was 35.82%.The serum levels of Presepsin, PCT, CRP and WBC in the death group were significantly higher than those in the survival group, and the PCIS score was significantly lower than that in the survival group(P<0.05).Multivariate Logistic regression analysis showed that Presepsin, PCT and PCIS scores were independent risk factors for death in children with sepsis(P<0.05).Pearson correlation analysis showed that the expression levels of Presepsin(r=-0.736, P<0.05) and PCT(r=-532, P<0.05) were negatively correlated with PCIS score.ROC curve analysis showed that the area under the Presepsin, PCT and PCIS score curves(AUC) were 0.851(95%CI:0.771-0.934), 0.806(95%CI:0.751-0.867) and 0748(95%CI:0.657-0.839).The AUC value of Presepsin combined with PCT was 0.942(95%CI:0.838-0.991), which was significantly better than the single Presepsin and PCT detection AUC(P<0.05).Conclusion: Presepsin combined with PCT has important clinical reference value in predicting mortality in children with sepsis.
- presesin /
- PCT /
- sepsis /
- mortality rate

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