血清Gal-3水平与脓毒症患者病情危重程度及预后关系的研究

曾永红

doi:10.13201/j.issn.1009-5918.2020.05.010

血清Gal-3水平与脓毒症患者病情危重程度及预后关系的研究

曾永红^,

- 自贡市第一人民医院急诊科(四川自贡, 643000)

详细信息

通讯作者: 曾永红,E-mail:13990090050@126.com

中图分类号: R737.9

收稿日期: 2019-10-29

Relationship between serum Gal-3 level and disease severity and prognosis in pyemia patients

ZENG Yonghong^,

- Department of Emergency, the First People's Hospital of Zigong, Zigong, Sichuan, 643000, China

More Information

Corresponding author: ZENG Yonghong, E-mail: 13990090050@126.com

Received Date: 29 October 2019

摘要

摘要: 目的:探究血清半乳糖凝集素-3(Gal-3)水平与脓毒症患者病情危重程度及预后的关系。方法:选择2014-02—2018-12期间收治的85例脓毒症患者和72例全身炎症反应综合征非脓毒症患者,分别作为脓毒症组和对照组,采用ELISA法检测两组患者血清Gal-3水平,分析两组患者血清中Gal-3水平。结果:脓毒症组患者体温、白细胞计数、APACHEⅡ评分、病死率、血清CRP及Gal-3水平均显著高于对照组(均P<0.05);脓毒性休克患者体温、白细胞计数、APACHEⅡ评分、病死率及血清Gal-3水平均显著高于未休克患者(均P<0.05);死亡脓毒症患者体温、白细胞计数、APACHEⅡ评分、血清CRP及Gal-3水平均显著高于存活患者(均P<0.05);Gal-3水平是脓毒症患者病情危急程度及预后的独立风险因素;Gal-3水平预测脓毒症病情的曲线下面积(AUC)为0.729,敏感度为71.80%,特异度为64.3%,95%CI为0.571~0.888;Gal-3水平预测脓毒症预后情况的AUC为0.692,敏感度为87.80%,特异度为50.00%,95%CI为0.574~0.810;脓毒症患者血清Gal-3水平与APACHEⅡ评分呈正相关(r=0.726,P=0.016)。结论:Gal-3水平在脓毒症患者中显著升高,对其病情严重程度和预后情况有一定的预测价值。
- 血清半乳糖凝集素-3 /
- 脓毒症 /
- 病情危重程度 /
- 预后
Abstract: Objective: To investigate the relationship between serum galectin-3(Gal-3) level and disease severity, prognosis in pyemia patients. Method: Eighty-five pyemia patients and 72 patients with systemic inflammatory response syndrome and non-pyemia admitted from February 2014 and December 2018 were enrolled. The two kinds of patients were divided into pyemia group and control group, respectively. Serum Gal-3 levels in both groups were measured by ELISA method. The Gal-3 levels in serum of the two groups were analyzed. Result: Body temperature, white blood cell count, score of acute physiology and chronic health evaluation systemⅡ(APACHE Ⅱ), mortality, serum CRP and Gal-3 levels in pyemia group were significantly higher than those in control group(P<0.05). Body temperature, white blood cell count, APACHE Ⅱ score, mortality and serum Gal-3 level in pyemia patients with shock were significantly higher than those without shock(P<0.05). Body temperature, white blood cell count, APACHE Ⅱ score, serum CRP and Gal-3 levels in dead pyemia patients were significantly higher than those in survival patients(P<0.05). Gal-3 level was an independent risk factor for severity and prognosis of pyemia patients. The area under the curve(AUC), sensitivity, specificity and 95%CI of Gal-3 level for predicting pyemia severity were 0.729, 71.80%, 64.3% and 0.571-0.888, respectively. The above 4 indexes of Gal-3 level for predicting prognosis were 0.692, 87.80%, 50.00% and 0.574-0.810, respectively. The serum Gal-3 level was positively correlated with APACHE Ⅱ score in pyemia patients(r=0.726, P=0.016).Conclusion: Gal-3 level is significantly increased in pyemia patients, which is of certain predictive value for disease severity and prognosis.
- serum galectin-3 /
- pyemia /
- disease severity /
- prognosis

HTML全文

参考文献(17)

[1]	黄丹.可溶性髓系细胞触发受体-1、降钙素原及超敏C反应蛋白在脓毒症诊断中的价值[J].内科急危重症杂志,2017,23(1):32-34.
[2]	Gao L,Liu X,Zhang D,et al.Early diagnosis of bacterial infection in patients with septicopyemia by laboratory analysis of PCT,CRP and IL-6[J].Exp Ther Med,2017,13(6):3479-3483.
[3]	Venkateshaiah S U,Eswaraiah M S,Annaiah H N,et al.Antimetastatic pectic polysaccharide from Decalepis hamiltonii;galectin-3 inhibition and immune-modulation[J].Clin Exp Metastasis,2017,34(2):1-14.
[4]	Goenka L,George M,Singh V,et al.Do ANGPTL-4 and galectin-3 reflect the severity of coronary artery disease[J].Ther Adv Cardiovasc Dis,2017,11(10):261-270.
[5]	景增秀.缺血性脑卒中患者血清中S100B、半乳糖凝集素-3和神经元特异性烯醇化酶的表达及意义[J].中国老年学杂志,2016,36(3):623-625.
[6]	Rhodes A,Evans L E,Alhazzani W,et al.Surviving Sepsis Campaign:International Guidelines for Management of Sepsis and Septic Shock:2016[J].Criti Care Med,2017,43(3):486-552.
[7]	Knaus W A,Zimmerman J E,Wagner D P,et al.APACHE-acute physiology and chronic health evaluation:a physiologically based classification system[J].Critical Care Medicine,1981,9(8):591-597.
[8]	吴先龙,周燕飞,张盛,等.集束化治疗依从率对脓毒症休克患者的疗效及预后影响的研究[J].中华医院感染学杂志,2017,27(15):3427-3430.
[9]	Leem A Y,Park M S,Park B H,et al.Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery[J].Yonsei Med J,2017,58(3):604-612.
[10]	陈丹,龙鼎,喻莉.降钙素、C反应蛋白及纤维蛋白原在老年脓毒症早期诊断中的价值比较[J].中国老年学杂志,2017,37(5):1223-1225.
[11]	罗运山,刘易林,邓霞梅,等.PCT、sTREM-1结合APACHEⅡ评分对脓毒症诊断和预后的价值[J].实用医学杂志,2017,33(4):586-590.
[12]	Schuetz P,Birkhahn R,Sherwin R,et al.Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients:Results From the Multicenter Procalcitonin MOnitoring SEpsis(MOSES)Study[J].Crit Care Med,2017,45(5):781-789.
[13]	He Y,Du W X,Jiang H Y,et al.Multiplex Cytokine Profiling Identifies Interleukin-27 as a Novel Biomarker for Neonatal Early Onset Sepsis[J].Shock,2017,47(2):140-147.
[14]	康中山,卜月梅,冯振中,等.降钙素原对脓毒症患者病情及预后的临床价值[J].内科急危重症杂志,2018,24(4):314-315,336.
[15]	汪秀莲,赵韧,王邦宁.血清半乳糖凝集素-3及炎症因子与冠脉病变程度和主要心脏不良事件的相关性[J].安徽医科大学学报,2017,52(2):261-264.
[16]	Nishikawa H,Suzuki H.Possible Role of Inflammation and Galectin-3 in Brain Injury after Subarachnoid Hemorrhage[J].Brain Sci,2018,8(2):30-40.
[17]	张丽丹,魏芳晶.半乳糖凝集素-3与动脉粥样硬化性损伤的研究进展[J].心脑血管病防治,2017,17(3):217-219.