血清hs-CRP、IL-6、凝血因子Ⅰ水平与急性脑梗死OCSP分型的相关性研究

濮万青; 杨扬; 田臻

doi:10.13201/j.issn.1009-5918.2019.09.015

血清hs-CRP、IL-6、凝血因子Ⅰ水平与急性脑梗死OCSP分型的相关性研究

- 淮安市淮阴医院神经内科(江苏淮安,223300)

详细信息

通讯作者: 濮万青,E-mail:184312199@qq.com

中图分类号: R743.33

收稿日期: 2018-09-06

Study on the relationship between hs-CRP, IL-6, factor I concentration in serum and different subtypes in patients with acute cerebral infarction

- Department of Neurology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu, 223300, China

More Information

Corresponding author: PU Wanqing, E-mail: 184312199@qq.com

Received Date: 06 September 2018

摘要

摘要: 目的: 探讨急性脑梗死患者血清高敏C反应蛋白(hs-CRP)、IL-6及凝血因子Ⅰ(FIB)的表达与OCSP分型的相关性。方法: 随机选取入住本院的240例急性脑梗死患者为研究组,按照OCSP进行分型,同时选取同期健康体检者120例为正常对照组,检测血清中hs-CRP、IL-6及FIB水平,分析三者与急性脑梗死OCSP分型的相关性以及三者之间相关性。结果: OCSP分型结果为:完全前循环性脑梗死(TACI)型45例(18.75%)、部分前循环性脑梗死(PACI)型70例(29.17%)、后循环性脑梗死(POCI)型30例(12.50%)、腔隙性脑梗死(LACI)型95例(39.58%),其中TACI型患者NIHSS评分最高(P<0.05)。研究组中血清hs-CRP、IL-6及FIB水平均显著高于对照组(P<0.05);hs-CRP、IL-6及FIB水平最高为TACI,其次为PACI,然后为POCI,最少为LACI,且组间比较差异有统计学意义(P<0.05);血清中hs-CRP、IL-6、FIB水平与急性脑梗死OCSP分型呈正相关性(r=0.889,P<0.05;r=0.795,P<0.05;r=0.797,P<0.05)。结论: 急性脑梗死患者血清中hs-CRP、IL-6及FIB水平与其OCSP分型密切相关,对急性脑梗死患者的治疗及预后具有较好指导意义。
- 脑梗死 /
- 高敏C反应蛋白 /
- 白介素-6 /
- 凝血因子Ⅰ
Abstract: Objective: To investigate the relationship between hs-CRP, IL-6, factor I concentration in serum and different subtypes in patients with acute cerebral infarction. Method: A total of 240 acute cerebral infarction in patients were randomly selected as a research group and were typed according to OCSP, 120 cases of healthy check-up were chosen as a normal control group. Levels of hs-CRP, IL-6 and factor I in serum were detected and correlation between them and acute cerebral infarction area and degree of subtypes in patients was analyzed. Result: Of the 240 acute cerebral infarction patients, 45 cases were TACI group, 70 cases were in the PACI group, 30 cases were in the POCI group and 95 cases were in the LACI group. The NIHSS score of TACI group was highest than other groups. Levels of hs-CRP, IL-6 and FIB in TACI group was highest, followed by PACI, POCI and LACI(P<0.05). Hs-CRP、IL-6 and factor I were positively related to the degree of different subtypes in patients with acute cerebral infarction(r=0.889, P<0.05; r=0.795, P<0.05; r=0.797, P<0.05).Conclusion: In patients with acute cerebral infarction, the larger infarction area or the more serious the degree of nerve injury, the higher the level of hs-CRP, IL-6 and FIB are positively related to the degree of neurological impairment and infarct size in patients with acute cerebral infarction, which has good guiding significance for treatment of patients with acute cerebral infarction.
- cerebral infarction /
- high sensitive C reactive protein /
- interleukin-6 /
- factor I

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