TSG-6蛋白在疾病模型中的研究进展

侯林林; 高艳霞

doi:10.13201/j.issn.1009-5918.2019.09.008

TSG-6蛋白在疾病模型中的研究进展

侯林林,
高艳霞^,

- 郑州大学第一附属医院急诊医学部(郑州,450052)
基金项目:
国家自然科学基金(No:81701893)

河南省科技厅科技攻关项目(No:162102310502)

详细信息

通讯作者: 高艳霞,E-mail:gaoyanxiazzu@163.com,博士,副主任医师,副教授,硕士研究生导师,郑大一附院急诊医学部副主任,郑东院区急诊内科负责人,全科医学科负责人,全科基地主任。中华急诊医学分会第九届委员会急性抗感染学组委员

中图分类号: R459.7

收稿日期: 2019-07-31

Research progress of TSG-6 protein in disease model

More Information

Corresponding author: , E-mail: gaoyanxiazzu@163.com

Received Date: 31 July 2019

摘要

- TSG-6蛋白 /
- 透明质酸 /
- 炎症反应 /
- 间充质干细胞
- tumor necrosis factor α stimulated gene 6 /
- hyaluronic acid /
- inflammatory /
- mesenchymal stem cell

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参考文献(32)

[1]	Coulson-Thomas VJ,Lauer ME,Soleman S,et al.Tumor Necrosis Factor-stimulated Gene-6(TSG-6) Is Constitutively Expressed in Adult Central Nervous System(CNS)and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury[J].J Biol Chem,2016,291(38):19939-19952.
[2]	McDonald B,McAvoy EF,Lam F,et al.Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids[J].J Exp Med,2008,205(4):915-927.
[3]	Lesley J,Gal I,Mahoney DJ,et al.TSG-6 modulates the interaction between hyaluronan and cell surface CD44[J].J Biol Chem,2004,279(24):25745-25754.
[4]	Dyer DP,Thomson JM,Hermant A,et al.TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8[J].J Immunol,2014,192(5):2177-21785.
[5]	He Z,Hua J,Qian D,et al.Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-alpha Stimulated Gene/Protein 6[J].Sci Rep,2016,6:38438.
[6]	Tan KT,McGrouther DA,Day AJ,et al.Characterization of hyaluronan and TSG-6 in skin scarring:differential distribution in keloid scars,normal scars and unscarred skin[J].J Eur Acad Dermatol Venereol,2011,25(3):317-327.
[7]	Lauer ME,Loftis J,de la Motte C,et al.Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices[J].Methods Mol Biol,2015,1229:543-548.
[8]	Ploutarchou P,Melo P,Day AJ,et al.Molecular analysis of the cumulus matrix:insights from mice with O-glycan-deficient oocytes[J].Reproduction,2015,149(5):533-543.
[9]	Day AJ,Milner CM.TSG-6:A multifunctional protein with anti-inflammatory and tissue-protective properties[J].Matrix Biol,2019,78-79:60-83.
[10]	Dyer DP,Salanga CL,Johns SC,et al.The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions[J].J Biol Chem,2016,291(24):12627-12640.
[11]	Song WJ,Li Q,Ryu MO,et al.TSG-6 released from intraperitoneally injected canine adipose tissue-derived mesenchymal stem cells ameliorate inflammatory bowel disease by inducing M2 macrophage switch in mice[J].Stem Cell Res Ther,2018,9(1):91.
[12]	Bryan C,Sammour I,Guerra K,et al.TNFalpha-stimulated protein 6(TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia[J].Pediatr Res,2019,85(3):390-397.
[13]	Um S,Kim HY,Lee JH,et al.TSG-6 secreted by mesenchymal stem cells suppresses immune reactions influenced by BMP-2 through p38 and MEK mitogen-activated protein kinase pathway[J].Cell Tissue Res,2017,368(3):551-561.
[14]	Liu L,Song H,Duan H,et al.TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling[J].Sci Rep,2016,6:30121.
[15]	McDonald B,Jenne CN,Zhuo L,et al.Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia[J].Am J Physiol Gastrointest Liver Physiol,2013,305(11):G797-806.
[16]	Li Q,Song WJ,Ryu MO,et al.TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates severe acute pancreatitis via ER stress downregulation in mice[J].Stem Cell Res Ther,2018,9(1):255.
[17]	Xu J,Zhen J,Zhu J,et al.Tumor necrosis factor-alpha induced protein 6 attenuates acute lung injury following paraquat exposure[J].Toxicol Mech Methods,2016,26(1):32-35.
[18]	许佳俊,郑建涛,朱景法.肿瘤坏死因子-α诱导蛋白6治疗减轻百草枯中毒大鼠急性肾损伤[J].中华危重病急救医学,2014,26(6):405-408.
[19]	Choi H,Lee RH,Bazhanov N,et al.Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages[J].Blood,2011,118(2):330-338.
[20]	Wang S,Lee C,Kim J,et al.Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice[J].Exp Mol Med,2017,49(9):e380.
[21]	Ni K,Gill A,Tseng V,et al.Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury[J].Respir Res,2018,19(1):107.
[22]	Watanabe R,Sato Y,Ozawa N,et al.Emerging Roles of Tumor Necrosis Factor-Stimulated Gene-6 in the Pathophysiology and Treatment of Atherosclerosis[J].Int J Mol Sci,2018,19(2):E465.
[23]	Zhang C,Zhang B,Wang H,et al.Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats[J].Heart Vessels,2017,32(12):1536-1545.
[24]	Bertling F,Bendix I,Drommelschmidt K,et al.Tumor necrosis factor-inducible gene 6 protein:A novel neuroprotective factor against inflammation-induced developmental brain injury[J].Exp Neurol,2016,279:283-289.
[25]	Chen M,Li X,Zhang X,et al.The inhibitory effect of mesenchymal stem cell on blood-brain barrier disruption following intracerebral hemorrhage in rats:contribution of TSG-6[J].J Neuroinflammation,2015,12:61.
[26]	Yang H,Tian W,Wang S,et al.TSG-6 secreted by bone marrow mesenchymal stem cells attenuates intervertebral disc degeneration by inhibiting the TLR2/NF-kappaB signaling pathway[J].Lab Invest,2018,98(6):755-772.
[27]	Mahoney DJ,Mikecz K,Ali T,et al.TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation[J].J Biol Chem,2008,283(38):25952-25962.
[28]	Lv YS,Gao R,Lin QM,et al.The role of TSG-6 and uroplakin Ⅲ in bladder pain syndrome/interstitial cystitis in rats and humans[J].Iran J Basic Med Sci,2017,20(11):1242-1249.
[29]	Roddy GW,Oh JY,Lee RH,et al.Action at a distance:systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6[J].Stem Cells,2011,29(10):1572-1579.
[30]	Song HB,Park SY,Ko JH,et al.Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner[J].Mol Ther,2018,26(1):162-172.
[31]	Di G,Du X,Qi X,et al.Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6-Dependent Stem Cell Activation and Macrophage Switch[J].Invest Ophthalmol Vis Sci,2017,58(10):4344-4354.
[32]	Xie J,Broxmeyer HE,Feng D,et al.Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6[J].Stem Cells,2015,33(2):468-478.