Autoimmune encephalitis associated with anti-neuronal antibodies:case analysis in emergengcy department and literature review
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Abstract: To explore the characteristics of clinical presentation,diagnosis,treatment and outcome of autoimmue encephalitis(AE)according to the latest international clinical guideline.The clinical data of 7 patients with AE were retrospectively analyzed.The mean age at oneset was 33.14±5.47.Among these patients,4 of them were definited to have anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis,while 2 of them probably got autoimmune encephalitis,the other 1 was possible to have autoimmune encephlitis.All the patients presented cognitive and memory dysfunction and psychological sysmptoms.4 of them had a seizure and involuntary movement.3 of them showed abnormal EEG and MRI signal,but none had abnormal CT signal.5 of them were accepted immunotherapy in 10 days from oneset and had a good prognosis,a short period of hospitalization.Testing for autoimmune disease related antibodies in blood and cerebrospinal fluid is necessary in order to avoid misdiagnosis.The earlier the patients diagnosised AE were accepted immunotherapy according to the latest clinical guideline,the better the outcome of these patients.
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