重症急性胰腺炎肠道屏障障碍及治疗研究进展

崔勇鹤; 王文俊

doi:10.13201/j.issn.1009-5918.2019.01.016

重症急性胰腺炎肠道屏障障碍及治疗研究进展

崔勇鹤,
王文俊^,

- 大连大学附属中山医院急诊(急腹症)外科(辽宁大连, 116001)

详细信息

通讯作者: 王文俊,E-mail:wwj20110101@sina.com

中图分类号: R657.5

收稿日期: 2018-10-24

Progress in intestinal barrier dysfunction and treatment of severe acute pancreatitis

CUI Yonghe,
WANG Wenjun^,

More Information

Corresponding author: WANG Wenjun, E-mail: wwj20110101@sina.com

Received Date: 24 October 2018

摘要

- 重症急性胰腺炎 /
- 肠道屏障功能障碍 /
- 发病机制 /
- 缺血再灌注 /
- 肠道菌群 /
- 免疫 /
- 治疗
Abstract: Severe acute pancreatitis (SAP) often causes damage to intestinal epithelial cells, destroys intestinal epithelial cell structure, increases intestinal mucosal permeability, and causes intestinal barrier dysfunction (IBD).IBD is prone to cause intestinal endotoxin and bacterial translocation, further accelerating the course of SAP, causing systemic inflammatory response or multiple organ failure (MODS), and even death.It can be seen that IBD plays a key role in pancreatic tissue necrosis infection and the development of SAP.Intestinal barriers, ie chemical barriers, physical barriers, immune barriers, and damage to biological barriers can interact with each other and promote positive feedback.Intestinal ischemia, inflammatory factors, intestinal flora, immune damage, intestinal nutrition and motivation and other factors together cause IBD.Therefore, the assessment and protection of intestinal barrier function is important for the treatment of SAP.This article reviews the pathogenesis of IBD and the treatment.
- sever acute pancreatitis /
- intestinal barrier dysfunction /
- mechanism /
- ischemia reperfusion /
- intestinal microflora /
- immune /
- treatment

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