亚低温对于心搏骤停患者复苏后心脏功能的影响

杜兰芳; 李昭屏; 马青变

doi:10.13201/j.issn.1009-5918.2019.01.006

亚低温对于心搏骤停患者复苏后心脏功能的影响

- 1 北京大学第三医院急诊科(北京, 100191);
- 2 北京大学第三医院心内科

详细信息

通讯作者: 马青变,E-mail:maqingbian@126.com

中图分类号: R459.7

收稿日期: 2018-11-16

The effect of therapeutic hypothermia on heart function in patients with cardiac arrest

More Information

Corresponding author: MA Qingbian, E-mail: maqingbian@126.com

Received Date: 16 November 2018

摘要

- 亚低温 /
- 心搏骤停 /
- 心脏功能 /
- 心肺复苏
Abstract: 45%-60% of the patients with cardiac arrest have heart dysfunction after successful resuscitation.Severe heart failure is a major determinate of mortality in the first 72 hafter restore of spontaneous circulation (ROSC).Target temperature management (TTM) is the only intervention to improve survival and neurological outcome of cardiac arrest patients.But whether TTM especially therapeutic hypothermia can improve heart dysfunction in CA patients after ROSC is controversy.
- therapeutic hypothermia /
- cardiac arrest /
- cardiac function /
- cardiopulmonary resuscitation

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参考文献(23)

[1]	Ayman AE.The Resuscitation Outcome:Revisit the Story of the Stony Heart[J].CHEST, 2005, 128:2835
[2]	Polderman KH, Varon J.Cool hemodynamics——the intricate interplay between therapeutic hypothermia and the post-cardiac arrest syndrome[J].Resuscitation, 2014, 85 (8):975-976.
[3]	Andreas E, Viesturs K, Anders O, et al.Effects of Therapeutic Hypothermia on Left Ventricular Function Assessed by Ultrasound Imaging[J].J Am Soc Echocardiogr, 2013, 26 (11):1353-1363.
[4]	Chung SP, Song FQ, Yua T, et al.Effect of therapeutic hypothermia vs δ-opioid receptor agonist on post resuscitation myocardial function in a rat model of CPR[J].Resuscitation, 2011, 82 (3):350-354.
[5]	Patrick M, Matthias G, Martin A, et al.Hypothermia and Postconditioning after Cardiopulmonary Resuscitation Reduce Cardiac Dysfunction by Modulating Inflammation, Apoptosis and Remodeling[J].PLoS One, 2009, 4 (10):e7588.
[6]	Yuan W, Wu JY, Zhao YZ, et al.Effects of Mild Hypothermia on Cardiac and Neurological Function in Piglets Under Pathological and Physiological Stress Conditions[J].Ther Hypothermia Temp Manag, 2018, Epub ahead of print.
[7]	Alogna A, Manninger M, Schwarzl M, et al.Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison With Dobutamine[J].Crit Care Med, 2015, 44 (3):e158.
[8]	Wu CJ, Li CS, Zhang Y, et al.Differences of postresuscitation myocardial dysfunction in ventricular fibrillation versus asphyxiation[J].Am J Emerg Med, 2013, 31:1690-1696.
[9]	Hsu CY, Huang CH, Chang WT, et al.Cardioprotective effect of therapeutic hypothermia for postresuscitation myocardial dysfunction[J].Shock, 2009, 32 (2):210-216.
[10]	Chien HH, Min ST, Chih YC, et al.Activation of mitochondrial STAT-3and reduced mitochondria damage during hypothermia treatment for post-cardiac arrest myocardial dysfunction[J].Basic Res Cardiol, 2015, 110:59.
[11]	朱芳芳, 季宪飞, 钟霞, 等.亚低温对复苏后猪心肌β-肾上腺素能受体信号通路的影响[J].中华危重病急救医学, 2018, 30 (2):134-139.
[12]	Nassal MMJ, Wan XP, Dale Z, et al.Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+channel function[J].Am J Physiol Heart Circ Physiol, 2017, 312 (5):H886-H895.d.
[13]	Ristagno G, Tantillo S, Sun S, et al.Hypothermia improves ventricular myocyte contractility under conditions of normal perfusion and after an interval of ischemia[J].Resuscitation, 2010, 81 (7):898-903.
[14]	Vivienne F, Cornelia D, Christoph W, et al.Cardioprotective effect of early therapeutic hypothermia during ischemia in an in vitro cardiomyocyte model[J].Resuscitation, 2013, 84S:S1-S7.
[15]	Schmidt SS, Ohler A, Post H, et al.Moderate hypothermia for severe cardiogenic shock (COOL Shock Study I&II)[J].Resuscitation, 2013, 84 (3):319-325.
[16]	Carsten Z, Christoph A, Anna K, et al.Mild therapeutic hypothermia in cardiogenic shock syndrome[J].Crit Care Med, 2012, 40:1715-1723.
[17]	Skulec R, Kovarnik T, Dostalova G, et al.Induction of mild hypothermia in cardiac arrest survivors presenting with cardiogenic shock syndrome[J].Acta Anaesthesiol Scand, 2008, 52 (2):188-194.
[18]	Nestaas E, Skranes JH, Stoylen A, et al.The myocardial function during and after whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy, a cohort study[J].Early Hum Dev, 2014, 90 (5):247-252.
[19]	Post H, Schmitto JD, Steendijk P, et al.Cardiac function during mild hypothermia in pigs:increased inotropy at the expense of diastolic dysfunction[J].Acta Physiol (Oxf), 2010, 199 (1):43-52.
[20]	Tsai MS, Barbut D, Tang W, et al.Rapid head cooling initiated coincident with cardiopulmonary resuscitation improves success of defibrillation and post-resuscitation myocardial function in a porcine model of prolonged cardiac arrest[J].J Am Coll Cardiol, 2008, 51 (20):1988-1990.
[21]	Kerans V, Espinoza A, Skulstad H, et al.Systolic left ventricular function is preserved during therapeutic hypothermia, also during increases in heart rate with impaired diastolic filling[J].Intensive Care Med Exp, 2015, 3 (1):41.
[22]	Karl B, Ronald W, Kyoo H.Myocardial Dysfunction After Resuscitation From Cardiac Arrest:An Example of Global Myocardial Stunning[J].JACC, 1996, 28 (1):232-240.
[23]	Xu TY, Tang WC, Ristagno G, et al.Postresuscitation myocardial diastolic dysfunction following prolonged ventricular fibrillation and cardiopulmonary resuscitation[J].Crit Care Med, 2008, 36 (1):188-192.