Abstract: Objective:To investigate the changes and significance of cerebral oxygen utilization coefficients (O₂ UC) and malonyldialdehyde (MDA) and superoxide dismutase (SOD) in patients with acute sever carbon monoxide poisoning (ASCOP) after treatment with Shuxuening injection.Method:One hundred and twenty patients with ASCOP admitted to our hospital from January 2015 to January 2017 were enrolled, and they were divided into control group and treatment group using a random number table.The patients in the control group were given conventional treatment including hyperbaric oxygen, prevention and treatment of cerebral edema, and promotion of brain cell metabolism, and those in the treatment group were given Shuxuening injection in addition to the conventional treatment.The course of treatment was 2 weeks for both groups.The changes in oxygen saturation of internal carotid artery blood (SaO₂) and oxygen saturation of internal jugular vein blood (SvO₂) were detected by blood gas analysis for all the patients before and 6 hours, 24 hours, 48 hours and 7 days after treatment, and then according to the rate of O₂ UC[O₂ UC=SaO₂-SvO₂/SaO₂], O₂ UC was calculated.The levels of MDA, SOD were measured in the same time.Before and after treatment, the changes of O₂ UC、MDA and SOD in two groups were compared;after treatment for 14 days, the improvement of clinical symptoms were observed;after treatment for 60 days, the incidence of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) were observed.Result:After treatment, both groups showed reductions in the levels of O₂ UC and MDA, but the treatment group had significantly greater reductions compared with the control group (P<0.05).Both groups showed a significant increase in SOD score after treatment, while the treatment group had a significantly greater inerease compared with the control group (P<0.05).There was a significant difference in the overall response rate between the treatment group and the control group (95% vs 85% P<0.05).The incidence of DEACMP after treatment between control group and treatment group (5.0% vs 11.7%, P<0.05).Conclusion:The treatment of Shuxuening injection combined with ganglioside in treatment of ASCOP patients can effectively reduce the O₂ UC, decrease the occurrence of DEACMP, thus it may improve the SOD, improving the prognosis.And the clinical curative effect is distinct.