年龄因素对腹部手术后急性胰岛素抵抗发生的影响

刘焕; 王辉; 狄高弘; 吴志林

doi:10.13201/j.issn.1009-5918.2016.12.008

年龄因素对腹部手术后急性胰岛素抵抗发生的影响

- 华中科技大学同济医学院附属协和医院麻醉科(武汉, 430022)

详细信息

通讯作者: 吴志林,E-mail:840916@qq.com

中图分类号: R656

收稿日期: 2016-10-06

Influence of age factor on the occurrence of acute insulin resistance for abdominal surgery patients

- Department of Anaesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

More Information

Corresponding author: WU Zhilin, E-mail: 840916@qq.com

Received Date: 06 October 2016

摘要

摘要: 目的:探讨年龄因素对腹部手术后急性胰岛素抵抗发生的影响。方法:选取我院实施腹部手术的60例患者,分为2组:年龄>60岁为老年组(S组),年龄<50岁为青年组(Y组)。测定患者术前,手术后6 h、12 h、24 h、72 h血糖,血胰岛素以及过氧化物酶歧化酶(SOD)、丙二醛(MDA)水平,计算胰岛素抵抗指数(HOMA-IR)。结果:S组患者腹部手术后HOMA-IR较Y组显著增高,同时MDA水平上升,SOD水平下降。结论:年龄是腹部手术后出现急性胰岛素抵抗的一个重要因素,其发生可能与老年患者氧化应激过强有关。
- 腹部手术 /
- 胰岛素抵抗 /
- 氧化应激 /
- 年龄
Abstract: Objective:To investigate the influence of age factor on the occurrence of acute insulin resistance for abdominal surgery patients.Method:Sixty cases of patients undergoing abdominal surgery were divided into two groups.senior group and young group.Blood sugar,insulin SOD and MDA were measured in five time points,pre-operation,6 h,12 h,24 h and 72 h post operation.Homeostasis model assessment insulin resistance (HOMA-IR) was calculated.Result:HOMA-IR and serum MDA were significantly higher and SOD was lower in senior group than young group at time points post operation.Conclusion:Age is an important factor for the occurrence of acute insulin resistance post abdominal operation.Oxidative stress may play a role in it.
- abdominal surgery /
- insulin resistance /
- oxidative stress /
- age

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